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Shared vulnerability for connectome alterations across psychiatric and neurological brain disorders.
de Lange, Siemon C; Scholtens, Lianne H; van den Berg, Leonard H; Boks, Marco P; Bozzali, Marco; Cahn, Wiepke; Dannlowski, Udo; Durston, Sarah; Geuze, Elbert; van Haren, Neeltje E M; Hillegers, Manon H J; Koch, Kathrin; Jurado, María Ángeles; Mancini, Matteo; Marqués-Iturria, Idoia; Meinert, Susanne; Ophoff, Roel A; Reess, Tim J; Repple, Jonathan; Kahn, René S; van den Heuvel, Martijn P.
Afiliación
  • de Lange SC; Connectome Lab, Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam, Netherlands.
  • Scholtens LH; Connectome Lab, Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam, Netherlands.
  • van den Berg LH; UMC Utrecht Brain Center, Department of Neurology, University Medical Center Utrecht, Utrecht, Netherlands.
  • Boks MP; UMC Utrecht Brain Center, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands.
  • Bozzali M; Department of Neuroscience, Brighton and Sussex Medical School, University of Sussex, Brighton, UK.
  • Cahn W; Neuroimaging Laboratory, Santa Lucia Foundation IRCCS, Rome, Italy.
  • Dannlowski U; UMC Utrecht Brain Center, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands.
  • Durston S; Altrecht Science, Altrecht Mental Health Institute, Utrecht, Netherlands.
  • Geuze E; Department of Psychiatry, University of Muenster, Muenster, Germany.
  • van Haren NEM; UMC Utrecht Brain Center, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands.
  • Hillegers MHJ; UMC Utrecht Brain Center, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands.
  • Koch K; Brain Research and Innovation Centre, Ministry of Defence, Utrecht, Netherlands.
  • Jurado MÁ; UMC Utrecht Brain Center, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands.
  • Mancini M; Department of Child and Adolescent Psychiatry/Psychology, Erasmus University Medical Center-Sophia Children's Hospital, Rotterdam, Netherlands.
  • Marqués-Iturria I; UMC Utrecht Brain Center, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands.
  • Meinert S; Department of Child and Adolescent Psychiatry/Psychology, Erasmus University Medical Center-Sophia Children's Hospital, Rotterdam, Netherlands.
  • Ophoff RA; Department of Neuroradiology & TUM-Neuroimaging Center (TUM-NIC), School of Medicine, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.
  • Reess TJ; Graduate School of Systemic Neurosciences GSN, Ludwig-Maximilians-Universität, Biocenter, Munich, Germany.
  • Repple J; Departament de Psicologia Clínica i Psicobiologia, Universitat de Barcelona, Barcelona, Spain.
  • Kahn RS; Institut de Neurociències, Universitat de Barcelona, Barcelona, Spain.
  • van den Heuvel MP; Institut de Recerca Pediàtrica Hospital Sant Joan de Déu (IRSJD), Barcelona, Spain.
Nat Hum Behav ; 3(9): 988-998, 2019 09.
Article en En | MEDLINE | ID: mdl-31384023
Macroscale white matter pathways are the infrastructure for large-scale communication in the human brain and a prerequisite for healthy brain function. Disruptions in the brain's connectivity architecture play an important role in many psychiatric and neurological brain disorders. Here we show that connections important for global communication and network integration are particularly vulnerable to brain alterations across multiple brain disorders. We report on a cross-disorder connectome study comprising in total 1,033 patients and 1,154 matched controls across 8 psychiatric and 4 neurological disorders. We extracted disorder connectome fingerprints for each of these 12 disorders and combined them into a 'cross-disorder disconnectivity involvement map' describing the level of cross-disorder involvement of each white matter pathway of the human brain network. Network analysis revealed connections central to global network communication and integration to display high disturbance across disorders, suggesting a general cross-disorder involvement and the importance of these pathways in normal function.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Encéfalo / Encefalopatías / Conectoma / Trastornos Mentales Tipo de estudio: Diagnostic_studies / Etiology_studies / Observational_studies Límite: Adolescent / Adult / Aged / Child / Female / Humans / Male / Middle aged Idioma: En Revista: Nat Hum Behav Año: 2019 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Encéfalo / Encefalopatías / Conectoma / Trastornos Mentales Tipo de estudio: Diagnostic_studies / Etiology_studies / Observational_studies Límite: Adolescent / Adult / Aged / Child / Female / Humans / Male / Middle aged Idioma: En Revista: Nat Hum Behav Año: 2019 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Reino Unido