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LRRK2 and membrane trafficking: nexus of Parkinson's disease.
Hur, Eun-Mi; Jang, Eun-Hae; Jeong, Ga Ram; Lee, Byoung Dae.
Afiliación
  • Hur EM; Department of Neuroscience, College of Veterinary Medicine, Research Institute for Veterinary Science, and BK21 PLUS Program for Creative Veterinary Science Research, Seoul National University, Seoul 08826, Korea.
  • Jang EH; Department of Neuroscience, College of Veterinary Medicine, Research Institute for Veterinary Science, and BK21 PLUS Program for Creative Veterinary Science Research, Seoul National University, Seoul 08826; Division of Bio-Medical Science & Technology, KIST School, Korea University of Science an
  • Jeong GR; Department of Neuroscience, Kyung Hee University, Seoul 02447, Korea.
  • Lee BD; Department of Neuroscience, Kyung Hee University, Seoul 02447; Department of Physiology, Kyung Hee University School of Medicine, Seoul 02447, Korea.
BMB Rep ; 52(9): 533-539, 2019 Sep.
Article en En | MEDLINE | ID: mdl-31383252
Recent evidence from genetics, animal model systems and biochemical studies suggests that defects in membrane trafficking play an important part in the pathophysiology of Parkinson's disease (PD). Mutations in leucine-rich repeat kinase 2 (LRRK2) constitute the most frequent genetic cause of both familial and sporadic PD, and LRRK2 has been suggested as a druggable target for PD. Although the precise physiological function of LRRK2 remains largely unknown, mounting evidence suggests that LRRK2 controls membrane trafficking by interacting with key regulators of the endosomal-lysosomal pathway and synaptic recycling. In this review, we discuss the genetic, biochemical and functional links between LRRK2 and membrane trafficking. Understanding the mechanism by which LRRK2 influences such processes may contribute to the development of disease-modifying therapies for PD. [BMB Reports 2019; 52(9): 533-539].
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de Parkinson / Vesículas Sinápticas / Proteína 2 Quinasa Serina-Treonina Rica en Repeticiones de Leucina Límite: Animals / Humans Idioma: En Revista: BMB Rep Asunto de la revista: BIOLOGIA MOLECULAR / BIOQUIMICA Año: 2019 Tipo del documento: Article Pais de publicación: Corea del Sur
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de Parkinson / Vesículas Sinápticas / Proteína 2 Quinasa Serina-Treonina Rica en Repeticiones de Leucina Límite: Animals / Humans Idioma: En Revista: BMB Rep Asunto de la revista: BIOLOGIA MOLECULAR / BIOQUIMICA Año: 2019 Tipo del documento: Article Pais de publicación: Corea del Sur