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Unravelling the receptor binding property of egg drop syndrome virus (EDSV) from the crystal structure of EDSV fiber head.
Song, Yapeng; Wei, Qiang; Liu, Yunchao; Feng, Hua; Chen, Yumei; Wang, Yanwei; Bai, Yilin; Xing, Guangxu; Deng, Ruiguang; Zhang, Gaiping.
Afiliación
  • Song Y; College of Animal Science and Veterinary Medicine, Henan Agricultural University, Zhengzhou 450002, China; Henan Provincial Key Laboratory of Animal Immunology, Henan Academy of Agricultural Sciences, Zhengzhou 450002, China.
  • Wei Q; Henan Provincial Key Laboratory of Animal Immunology, Henan Academy of Agricultural Sciences, Zhengzhou 450002, China.
  • Liu Y; Henan Provincial Key Laboratory of Animal Immunology, Henan Academy of Agricultural Sciences, Zhengzhou 450002, China.
  • Feng H; Henan Provincial Key Laboratory of Animal Immunology, Henan Academy of Agricultural Sciences, Zhengzhou 450002, China.
  • Chen Y; School of Life Sciences, Zhengzhou University, Zhengzhou 450001, China.
  • Wang Y; School of Life Sciences, Zhengzhou University, Zhengzhou 450001, China.
  • Bai Y; College of Veterinary Medicine, Northwest A&F University, Yangling 712100, China.
  • Xing G; Henan Provincial Key Laboratory of Animal Immunology, Henan Academy of Agricultural Sciences, Zhengzhou 450002, China.
  • Deng R; Henan Provincial Key Laboratory of Animal Immunology, Henan Academy of Agricultural Sciences, Zhengzhou 450002, China.
  • Zhang G; College of Animal Science and Veterinary Medicine, Henan Agricultural University, Zhengzhou 450002, China; Henan Provincial Key Laboratory of Animal Immunology, Henan Academy of Agricultural Sciences, Zhengzhou 450002, China; Jiangsu Co-innovation Center for Prevention and Control of Important Anima
Int J Biol Macromol ; 139: 587-595, 2019 Oct 15.
Article en En | MEDLINE | ID: mdl-31381914
Egg drop syndrome virus (EDSV) is an avian adenovirus that causes markedly decrease in egg production, and in the quality of the eggs when it infects chickens. Until now, EDSV virus-cell interactions are poorly understood, and the cellular receptor is still unknown. In the present study, we determined the atomic structure of the fiber head of EDSV (residues 377-644) at 2.74 Šresolution. Structure comparison with the (chick embryo lethal orphan) CELO long fiber head and human adenovirus fiber heads reveals that the avian adenovirus may interact with the same attachment factor in a unique fashion. Based on the previous studies of CELO virus, we assumed that the chicken coxsackievirus and adenovirus receptor (CAR) may be the attachment factor. We then demonstrate that the chicken CAR serves as a cellular attachment factor for EDSV based on three lines of evidences. Taken together, the results presented here are helpful for further exploring the pathogenesis related to the interaction between EDSV and host cells, and may be used for vaccine development and intervention strategies against EDSV infection.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Conformación Proteica / Receptores Virales / Modelos Moleculares / Proteínas de la Cápside / Atadenovirus Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Int J Biol Macromol Año: 2019 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Conformación Proteica / Receptores Virales / Modelos Moleculares / Proteínas de la Cápside / Atadenovirus Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Int J Biol Macromol Año: 2019 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos