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Profile of a Highly Selective Quaternized Pyrrolidine Betaine αvß6 Integrin Inhibitor-(3S)-3-(3-(3,5-Dimethyl-1H-pyrazol-1-yl)phenyl)-4-((1S and 1R,3R)-1-methyl-3-(2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl)pyrrolidin-1-ium-1-yl)butanoate Synthesized by Stereoselective Methylation.
Barrett, Tim N; Taylor, Jonathan A; Barker, Daniel; Procopiou, Panayiotis A; Thompson, James D F; Barrett, John; Le, Joelle; Lynn, Sean M; Pogany, Peter; Pratley, Cassie; Pritchard, John M; Roper, James A; Rowedder, James E; Slack, Robert J; Vitulli, Giovanni; Macdonald, Simon J F; Kerr, William J.
Afiliación
  • Barrett TN; Medicinal Science & Technology , GlaxoSmithKline Medicines Research Centre , Gunnels Wood Road , Stevenage , SG1 2NY , United Kingdom.
  • Taylor JA; Medicinal Science & Technology , GlaxoSmithKline Medicines Research Centre , Gunnels Wood Road , Stevenage , SG1 2NY , United Kingdom.
  • Barker D; Medicinal Science & Technology , GlaxoSmithKline Medicines Research Centre , Gunnels Wood Road , Stevenage , SG1 2NY , United Kingdom.
  • Procopiou PA; Medicinal Science & Technology , GlaxoSmithKline Medicines Research Centre , Gunnels Wood Road , Stevenage , SG1 2NY , United Kingdom.
  • Thompson JDF; Medicinal Science & Technology , GlaxoSmithKline Medicines Research Centre , Gunnels Wood Road , Stevenage , SG1 2NY , United Kingdom.
  • Barrett J; Department of Pure & Applied Chemistry , University of Strathclyde , 295 Cathedral Street , Glasgow , G1 1XL , U.K.
  • Le J; Medicinal Science & Technology , GlaxoSmithKline Medicines Research Centre , Gunnels Wood Road , Stevenage , SG1 2NY , United Kingdom.
  • Lynn SM; Medicinal Science & Technology , GlaxoSmithKline Medicines Research Centre , Gunnels Wood Road , Stevenage , SG1 2NY , United Kingdom.
  • Pogany P; Medicinal Science & Technology , GlaxoSmithKline Medicines Research Centre , Gunnels Wood Road , Stevenage , SG1 2NY , United Kingdom.
  • Pratley C; Medicinal Science & Technology , GlaxoSmithKline Medicines Research Centre , Gunnels Wood Road , Stevenage , SG1 2NY , United Kingdom.
  • Pritchard JM; Medicinal Science & Technology , GlaxoSmithKline Medicines Research Centre , Gunnels Wood Road , Stevenage , SG1 2NY , United Kingdom.
  • Roper JA; Medicinal Science & Technology , GlaxoSmithKline Medicines Research Centre , Gunnels Wood Road , Stevenage , SG1 2NY , United Kingdom.
  • Rowedder JE; Medicinal Science & Technology , GlaxoSmithKline Medicines Research Centre , Gunnels Wood Road , Stevenage , SG1 2NY , United Kingdom.
  • Slack RJ; Medicinal Science & Technology , GlaxoSmithKline Medicines Research Centre , Gunnels Wood Road , Stevenage , SG1 2NY , United Kingdom.
  • Vitulli G; Medicinal Science & Technology , GlaxoSmithKline Medicines Research Centre , Gunnels Wood Road , Stevenage , SG1 2NY , United Kingdom.
  • Macdonald SJF; Medicinal Science & Technology , GlaxoSmithKline Medicines Research Centre , Gunnels Wood Road , Stevenage , SG1 2NY , United Kingdom.
  • Kerr WJ; Medicinal Science & Technology , GlaxoSmithKline Medicines Research Centre , Gunnels Wood Road , Stevenage , SG1 2NY , United Kingdom.
J Med Chem ; 62(16): 7543-7556, 2019 08 22.
Article en En | MEDLINE | ID: mdl-31381331
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pirrolidinas / Betaína / Integrinas / Compuestos de Amonio Cuaternario Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2019 Tipo del documento: Article País de afiliación: Reino Unido Pais de publicación: Estados Unidos
Texto completo
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XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pirrolidinas / Betaína / Integrinas / Compuestos de Amonio Cuaternario Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2019 Tipo del documento: Article País de afiliación: Reino Unido Pais de publicación: Estados Unidos