Tanshinone IIA ameliorates non-alcoholic fatty liver disease through targeting peroxisome proliferator-activated receptor gamma and toll-like receptor 4.

Huang, Lu; Ding, Wei; Wang, Ming-Qiang; Wang, Zheng-Gen; Chen, Hong-Hui; Chen, Wen; Yang, Qiong; Lu, Ting-Na; Yang, Qing; He, Ji-Man

Huang, Lu; Ding, Wei; Wang, Ming-Qiang; Wang, Zheng-Gen; Chen, Hong-Hui; Chen, Wen; Yang, Qiong; Lu, Ting-Na; Yang, Qing; He, Ji-Man.

Afiliación

Huang L; Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong Province, China.
Ding W; Department of Gastroenterology, The Second Affiliated Hospital of University of South China, Hengyang, Hunan Province, China.
Wang MQ; Department of Urology, The First Affiliated Hospital of Guiyang College of Traditional Chinese Medicine, Guiyang, Guizhou Province, China.
Wang ZG; Guiyang College of Traditional Chinese Medicine, Guiyang, Guizhou Province, China.
Chen HH; Department of Gastroenterology, The Second Affiliated Hospital of University of South China, Hengyang, Hunan Province, China.
Chen W; Department of Gastroenterology, The Second Affiliated Hospital of University of South China, Hengyang, Hunan Province, China.
Yang Q; Department of Gastroenterology, The Second Affiliated Hospital of University of South China, Hengyang, Hunan Province, China.
Lu TN; Department of Gastroenterology, The Second Affiliated Hospital of University of South China, Hengyang, Hunan Province, China.
Yang Q; Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong Province, China.
He JM; Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong Province, China.

J Int Med Res ; 47(10): 5239-5255, 2019 Oct.

Article en En | MEDLINE | ID: mdl-31378113

Asunto(s)

Abietanos/uso terapéutico; Enfermedad del Hígado Graso no Alcohólico/tratamiento farmacológico; Enfermedad del Hígado Graso no Alcohólico/metabolismo; PPAR gamma/metabolismo; Receptor Toll-Like 4/metabolismo; Abietanos/farmacología; Animales; Peso Corporal/efectos de los fármacos; Lípidos/sangre; Hígado/efectos de los fármacos; Hígado/enzimología; Hígado/patología; Masculino; Malondialdehído/sangre; Malondialdehído/metabolismo; FN-kappa B/metabolismo; Enfermedad del Hígado Graso no Alcohólico/genética; Tamaño de los Órganos/efectos de los fármacos; Oxidación-Reducción; PPAR gamma/genética; ARN Mensajero/genética; ARN Mensajero/metabolismo; Ratas Sprague-Dawley; Receptor Toll-Like 4/genética

Palabras clave

Tanshinone IIA; inflammation; non-alcoholic fatty liver disease; oxidative stress; peroxisome proliferator-activated receptor gamma; toll-like receptor 4

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Abietanos / PPAR gamma / Receptor Toll-Like 4 / Enfermedad del Hígado Graso no Alcohólico Límite: Animals Idioma: En Revista: J Int Med Res Año: 2019 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido

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