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Enhanced anticancer efficiency of doxorubicin against human glioma by natural borneol through triggering ROS-mediated signal.
Cao, Wen-Qiang; Li, Ying; Hou, Ya-Jun; Yang, Mao-Xun; Fu, Xue-Qi; Zhao, Bai-Song; Jiang, Han-Ming; Fu, Xiao-Yan.
Afiliación
  • Cao WQ; School of Life Sciences, Jilin University, Changchun, Jilin, 130012, China; Zhuhai Hopegenes Medical & Phamaceutical Institute, Hengqin New Area, Zhuhai, Guangdong, 519000, China.
  • Li Y; Department of Pediatrics, Shandong Provincial ENT Hospital Affiliated to Shandong University, Jinan, Shandong, 250021, China.
  • Hou YJ; Department of Biochemistry, Basic Medicine College, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian, Shandong, 271000, China.
  • Yang MX; Zhuhai Hopegenes Medical & Phamaceutical Institute, Hengqin New Area, Zhuhai, Guangdong, 519000, China.
  • Fu XQ; School of Life Sciences, Jilin University, Changchun, Jilin, 130012, China.
  • Zhao BS; Zhuhai Hopegenes Medical & Phamaceutical Institute, Hengqin New Area, Zhuhai, Guangdong, 519000, China.
  • Jiang HM; Department of Biochemistry, Basic Medicine College, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian, Shandong, 271000, China. Electronic address: hmjiang1976@126.com.
  • Fu XY; Department of Biochemistry, Basic Medicine College, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian, Shandong, 271000, China. Electronic address: txyfu66@163.com.
Biomed Pharmacother ; 118: 109261, 2019 Oct.
Article en En | MEDLINE | ID: mdl-31374355
Doxorubicin (DOX) as a first-line chemotherapeutic drug has been widely used for therapy of human cancers. However, side effects and chemo-resistance severely blocked its clinic application. Herein, natural borneol (NB) as a novel monoterpenoid chemosensitizer was found to have the potential to increase the blood brain barrier (BBB) permeability and intracellular uptake of DOX in vitro, and synergistically enhanced DOX-induced cytotoxicity in human glioma cells. NB treatment significantly potentiated DOX-induced G2/M cell cycle arrest by triggering reactive oxygen species (ROS)-mediated DNA damage. NB also enhanced DOX-induced dysfunction of MAPKs and PI3 K/AKT pathways. Furthermore, U251 human glioma xenograft growth in vivo was also effectively inhibited by combined treatment of DOX with NB through induction of G2/M-phase arrest and antiangiogenesis. Taken together, our finding validated that NB could act as novel chemosensitizer to enhance DOX-induced anticancer efficacy, and strategy of using NB and DOX could be a high efficient way in therapy of human cancers.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Canfanos / Transducción de Señal / Doxorrubicina / Especies Reactivas de Oxígeno / Glioma / Antineoplásicos Tipo de estudio: Prognostic_studies Límite: Animals / Humans / Male Idioma: En Revista: Biomed Pharmacother Año: 2019 Tipo del documento: Article País de afiliación: China Pais de publicación: Francia
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Canfanos / Transducción de Señal / Doxorrubicina / Especies Reactivas de Oxígeno / Glioma / Antineoplásicos Tipo de estudio: Prognostic_studies Límite: Animals / Humans / Male Idioma: En Revista: Biomed Pharmacother Año: 2019 Tipo del documento: Article País de afiliación: China Pais de publicación: Francia