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Clinically Significant Fibrosis Is Associated With Longitudinal Increases in Fibrosis-4 and Nonalcoholic Fatty Liver Disease Fibrosis Scores.
Patel, Preya Janubhai; Cheng, Johnson Chieh-Yu; Banh, Xuan; Gracen, Lucy; Radford-Smith, Daniel; Hossain, Fabrina; Horsfall, Leigh Ula; Hayward, Kelly Lee; Williams, Suzanne; Johnson, Tracey; Brown, Nigel Neil; Saad, Nivene; Stuart, Katherine Anne; Russell, Anthony William; Valery, Patricia Casarolli; Clouston, Andrew Donald; Irvine, Katharine Margaret; Bernard, Anne; Powell, Elizabeth Ellen.
Afiliación
  • Patel PJ; Department of Gastroenterology and Hepatology, Princess Alexandra Hospital, Brisbane, Australia; Centre for Liver Disease Research, University of Queensland, Brisbane, Australia.
  • Cheng JC; Centre for Liver Disease Research, University of Queensland, Brisbane, Australia.
  • Banh X; Centre for Liver Disease Research, University of Queensland, Brisbane, Australia.
  • Gracen L; Centre for Liver Disease Research, University of Queensland, Brisbane, Australia.
  • Radford-Smith D; Faculty of Medicine, University of Queensland, Brisbane, Australia.
  • Hossain F; Inala Primary Care, Brisbane, Australia.
  • Horsfall LU; Department of Gastroenterology and Hepatology, Princess Alexandra Hospital, Brisbane, Australia; Centre for Liver Disease Research, University of Queensland, Brisbane, Australia.
  • Hayward KL; Centre for Liver Disease Research, University of Queensland, Brisbane, Australia.
  • Williams S; Inala Primary Care, Brisbane, Australia.
  • Johnson T; Inala Primary Care, Brisbane, Australia.
  • Brown NN; Pathology Queensland, Brisbane, Australia.
  • Saad N; Faculty of Medicine, University of Queensland, Brisbane, Australia; Department of Radiology, Princess Alexandra Hospital, Brisbane, Australia.
  • Stuart KA; Department of Gastroenterology and Hepatology, Princess Alexandra Hospital, Brisbane, Australia.
  • Russell AW; Faculty of Medicine, University of Queensland, Brisbane, Australia; Department of Diabetes and Endocrinology, Princess Alexandra Hospital, Brisbane, Australia.
  • Valery PC; QIMR Berghofer Medical Research Institute, Brisbane, Australia.
  • Clouston AD; Centre for Liver Disease Research, University of Queensland, Brisbane, Australia.
  • Irvine KM; Centre for Liver Disease Research, University of Queensland, Brisbane, Australia; Mater Research, Translational Research Institute, University of Queensland, Brisbane, Australia.
  • Bernard A; QFAB Bioinformatics, Institute for Molecular Bioscience, Queensland Bioscience Precinct, University of Queensland, Brisbane, Australia.
  • Powell EE; Department of Gastroenterology and Hepatology, Princess Alexandra Hospital, Brisbane, Australia; Centre for Liver Disease Research, University of Queensland, Brisbane, Australia. Electronic address: e.powell@uq.edu.au.
Clin Gastroenterol Hepatol ; 18(3): 710-718.e4, 2020 03.
Article en En | MEDLINE | ID: mdl-31352092
BACKGROUND & AIMS: There is limited knowledge regarding the longitudinal utility of biomarkers of fibrosis, such as the nonalcoholic fatty liver disease (NAFLD) fibrosis score (NFS) or the fibrosis-4 score (FIB-4) score. We examined longitudinal changes in the NFS and the FIB-4 score in patients with NAFLD, with and without clinically significant fibrosis (CSF). METHODS: We performed a retrospective study of 230 patients with NAFLD, collecting clinical and laboratory records to calculate NFS and FIB-4 scores at 6 monthly intervals for 5 years before hepatology assessment of fibrosis. Linear mixed models with random intercept and slope and adjusted for age at baseline were used to assess the progression of NFS and log-transformed FIB-4 scores over time in subjects with and without CSF, determined by liver stiffness measurements of 8.2 kPa or greater. RESULTS: Patients had a median of 11 (minimum, 10; maximum, 11) retrospective observations over a median time period of 5 years (minimum, 4.5 y; maximum, 5 y). Of patients with low baseline NFS and FIB-4 scores, 31.11% and 37.76%, respectively, had CSF at the time of hepatology assessment. There was a correlation between NFS and log10 FIB-4 over time (repeated measure r = 0.55; 95% CI, 0.52-0.59). The rate of increase in NFS and log10 FIB-4 was significantly higher in patients with than without CSF (both P < .001). Predicted NFS increased by 0.17 and 0.06 units per year in subjects with and without CSF, respectively. Predicted log10 FIB-4 score increased by 0.032 and 0.0003 units per year in subjects with and without CSF, respectively. CONCLUSIONS: Noninvasively measured fibrosis scores increase progressively in patients with NAFLD and CSF. Further studies are needed to determine whether repeated measurements can identify patients at risk for CSF.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad del Hígado Graso no Alcohólico Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Aspecto: Patient_preference Límite: Humans Idioma: En Revista: Clin Gastroenterol Hepatol Asunto de la revista: GASTROENTEROLOGIA Año: 2020 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad del Hígado Graso no Alcohólico Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Aspecto: Patient_preference Límite: Humans Idioma: En Revista: Clin Gastroenterol Hepatol Asunto de la revista: GASTROENTEROLOGIA Año: 2020 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Estados Unidos