[Bepridil and bundle of His block. Apropos of a case].

Marchand, X; Zannier, D; Pathé, M; Baron, B; Hotton, J M; Kahn, J C

[Bepridil and bundle of His block. Apropos of a case]. / Bépridil et bloc intrahisien. A propos d'un cas.

Marchand, X; Zannier, D; Pathé, M; Baron, B; Hotton, J M; Kahn, J C.

Afiliación

Marchand X; Service de cardiologie, CHI de Poissy.

Arch Mal Coeur Vaiss ; 81(3): 339-42, 1988 Mar.

Article en Fr | MEDLINE | ID: mdl-3134872

RESUMEN

The first case of atrioventricular block located in His bundle observed during oral treatment with bepridil is reported; the block subsided when the drug was discontinued and reappeared when it was reintroduced. Electrophysiological studies performed with bepridil have shown that, as could be foreseen from its beneficial or undesirable effects, this calcium antagonist has some properties of Vaughan Williams' class I antiarrhythmic agents and alters subnodal conduction. Clinical studies indicate that in therapeutic doses this alteration has little or no significance, but it may reach clinical expression when latent of patient pre-existing disorders of conduction within or below His bundle are present.

Asunto(s)

Bloqueo de Rama/inducido químicamente; Bloqueadores de los Canales de Calcio/efectos adversos; Pirrolidinas/efectos adversos; Bepridil; Fascículo Atrioventricular; Electrocardiografía; Electrofisiología; Sistema de Conducción Cardíaco/efectos de los fármacos; Humanos; Masculino; Persona de Mediana Edad; Pirrolidinas/farmacología

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pirrolidinas / Bloqueo de Rama / Bloqueadores de los Canales de Calcio Límite: Humans / Male / Middle aged Idioma: Fr Revista: Arch Mal Coeur Vaiss Año: 1988 Tipo del documento: Article Pais de publicación: Francia

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