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Autoimmune pathways in mice and humans are blocked by pharmacological stabilization of the TYK2 pseudokinase domain.
Burke, James R; Cheng, Lihong; Gillooly, Kathleen M; Strnad, Joann; Zupa-Fernandez, Adriana; Catlett, Ian M; Zhang, Yifan; Heimrich, Elizabeth M; McIntyre, Kim W; Cunningham, Mark D; Carman, Julie A; Zhou, Xiadi; Banas, Dana; Chaudhry, Charu; Li, Sha; D'Arienzo, Celia; Chimalakonda, Anjaneya; Yang, XiaoXia; Xie, Jenny H; Pang, Jian; Zhao, Qihong; Rose, Shawn M; Huang, Jinwen; Moslin, Ryan M; Wrobleski, Stephen T; Weinstein, David S; Salter-Cid, Luisa M.
Afiliación
  • Burke JR; Immunosciences Discovery Biology, Bristol-Myers Squibb Research and Development, Princeton, NJ 08543, USA. james.burke@bms.com.
  • Cheng L; Immunosciences Discovery Biology, Bristol-Myers Squibb Research and Development, Princeton, NJ 08543, USA.
  • Gillooly KM; Immunosciences Discovery Biology, Bristol-Myers Squibb Research and Development, Princeton, NJ 08543, USA.
  • Strnad J; Immunosciences Discovery Biology, Bristol-Myers Squibb Research and Development, Princeton, NJ 08543, USA.
  • Zupa-Fernandez A; Immunosciences Discovery Biology, Bristol-Myers Squibb Research and Development, Princeton, NJ 08543, USA.
  • Catlett IM; Innovative Medicines Development, Bristol-Myers Squibb Research and Development, Princeton, NJ 08543, USA.
  • Zhang Y; Immunosciences Discovery Biology, Bristol-Myers Squibb Research and Development, Princeton, NJ 08543, USA.
  • Heimrich EM; Immunosciences Discovery Biology, Bristol-Myers Squibb Research and Development, Princeton, NJ 08543, USA.
  • McIntyre KW; Immunosciences Discovery Biology, Bristol-Myers Squibb Research and Development, Princeton, NJ 08543, USA.
  • Cunningham MD; Translational Medicine, Bristol-Myers Squibb Research and Development, Princeton, NJ 08543, USA.
  • Carman JA; Translational Medicine, Bristol-Myers Squibb Research and Development, Princeton, NJ 08543, USA.
  • Zhou X; Immunosciences Discovery Biology, Bristol-Myers Squibb Research and Development, Princeton, NJ 08543, USA.
  • Banas D; Translational Medicine, Bristol-Myers Squibb Research and Development, Princeton, NJ 08543, USA.
  • Chaudhry C; Leads Discovery and Optimization, Bristol-Myers Squibb Research and Development, Princeton, NJ 08543, USA.
  • Li S; Leads Discovery and Optimization, Bristol-Myers Squibb Research and Development, Princeton, NJ 08543, USA.
  • D'Arienzo C; Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Research and Development, Princeton, NJ 08543, USA.
  • Chimalakonda A; Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Research and Development, Princeton, NJ 08543, USA.
  • Yang X; Immunosciences Discovery Biology, Bristol-Myers Squibb Research and Development, Princeton, NJ 08543, USA.
  • Xie JH; Immunosciences Discovery Biology, Bristol-Myers Squibb Research and Development, Princeton, NJ 08543, USA.
  • Pang J; Immunosciences Discovery Biology, Bristol-Myers Squibb Research and Development, Princeton, NJ 08543, USA.
  • Zhao Q; Immunosciences Discovery Biology, Bristol-Myers Squibb Research and Development, Princeton, NJ 08543, USA.
  • Rose SM; Innovative Medicines Development, Bristol-Myers Squibb Research and Development, Princeton, NJ 08543, USA.
  • Huang J; Immunosciences Discovery Biology, Bristol-Myers Squibb Research and Development, Princeton, NJ 08543, USA.
  • Moslin RM; Immunosciences Discovery Chemistry, Bristol-Myers Squibb Research and Development, Princeton, NJ 08543, USA.
  • Wrobleski ST; Immunosciences Discovery Chemistry, Bristol-Myers Squibb Research and Development, Princeton, NJ 08543, USA.
  • Weinstein DS; Immunosciences Discovery Chemistry, Bristol-Myers Squibb Research and Development, Princeton, NJ 08543, USA.
  • Salter-Cid LM; Immunosciences Discovery Biology, Bristol-Myers Squibb Research and Development, Princeton, NJ 08543, USA.
Sci Transl Med ; 11(502)2019 07 24.
Article en En | MEDLINE | ID: mdl-31341059
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Transducción de Señal / Autoinmunidad / TYK2 Quinasa Límite: Animals / Female / Humans Idioma: En Revista: Sci Transl Med Asunto de la revista: CIENCIA / MEDICINA Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
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XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Transducción de Señal / Autoinmunidad / TYK2 Quinasa Límite: Animals / Female / Humans Idioma: En Revista: Sci Transl Med Asunto de la revista: CIENCIA / MEDICINA Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos