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Expression of UTX Indicates Poor Prognosis in Patients With Luminal Breast Cancer and is Associated With MMP-11 Expression.
Kim, Gi Jeong; Kim, Dong-Hoon; Min, Kyueng-Whan; Chae, Seoung Wan; Kim, Se Hoon; Son, Byoung Kwan; Moon, Kyoung Min; Kim, Young Hwan.
Afiliación
  • Kim GJ; Department of Pathology, Gachon University Gil Medical Center, Gachon University College of Medicine, Incheon.
  • Kim DH; Department of Medicine, Yonsei University Graduate School.
  • Min KW; Department of Pathology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul.
  • Chae SW; Department of Pathology, Hanyang University Guri Hospital, Hanyang University College of Medicine, Guri, Gyeonggi-do.
  • Kim SH; Department of Pathology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul.
  • Son BK; Department of Pathology, Yonsei University College of Medicine, Severance Hospital.
  • Moon KM; Department of Internal Medicine, Eulji Hospital, Eulji University School of Medicine, Seoul.
  • Kim YH; Department of Internal Medicine, Gangneung Asan Hospital, University of Ulsan College of Medicine, Gangneung.
Appl Immunohistochem Mol Morphol ; 28(7): 544-550, 2020 08.
Article en En | MEDLINE | ID: mdl-31335488
Ubiquitously transcribed tetratricopeptide repeat, X chromosome (UTX) is involved in the epigenetic regulation. A previous mouse xenograft study revealed that UTX knockdown is associated with downregulated expression of matrix metalloproteinase-11 (MMP-11). The authors investigated 224 cases of breast cancer from Kangbuk Samsung Medical Center between 2000 and 2005. Nuclear UTX and cytoplasmic MMP-11 expressions were assessed using immunohistochemistry of tumor tissue microarray specimens. The relationships between the expression of UTX, MMP-11, and patients' outcomes were analyzed. UTX expression was significantly associated with high histologic grade, lymphatic invasion, vascular invasion, and tumoral expression of MMP-11. Survival analysis revealed that patients with UTX expression had a poorer overall survival rate (P=0.010) as well as diminished disease-free survival rate (P=0.001). The prognostic power of UTX expression was significant in patients with luminal-type breast cancer (P=0.027, overall survival; P=0.008, disease-free survival). Validation of UTX can provide further prognostic information beyond traditional indicators and represents a potential therapeutic target for breast cancer.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Biomarcadores de Tumor / Metaloproteinasa 11 de la Matriz / Histona Demetilasas Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Animals / Female / Humans / Middle aged Idioma: En Revista: Appl Immunohistochem Mol Morphol Asunto de la revista: BIOLOGIA MOLECULAR / HISTOCITOQUIMICA Año: 2020 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Biomarcadores de Tumor / Metaloproteinasa 11 de la Matriz / Histona Demetilasas Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Animals / Female / Humans / Middle aged Idioma: En Revista: Appl Immunohistochem Mol Morphol Asunto de la revista: BIOLOGIA MOLECULAR / HISTOCITOQUIMICA Año: 2020 Tipo del documento: Article Pais de publicación: Estados Unidos