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Association between CD4+, CD25+, FOXP3+ Regulatory T-cells and Cardiovascular Complications in Diabetic Patients Type 1.
El-Shabrawy, Reham M; Ahmed, Azza M; Selim, Fayrouz O; Said, Nora M.
Afiliación
  • El-Shabrawy RM; Department of Medical Microbiology & Immunology, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
  • Ahmed AM; Department of Clinical Pathology, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
  • Selim FO; Department of Internal Medicine, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
  • Said NM; Department of Clinical Pathology, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Egypt J Immunol ; 26(1): 129-139, 2019 Jan.
Article en En | MEDLINE | ID: mdl-31333003
T regulatory cells (Tregs) are a cornerstone regulator for immune responses and inflammatory reactions. Abnormal number or function of Tregs causes deranged immune response that increases the autoimmune disorders and inflammatory conditions. Type 1 diabetes mellitus is an autoimmune disease associated with many complications, of which, Cardiovascular complications are fundamental and responsible for profound morbidity and mortality. Understanding the immunopathogenesis of these disorders allows early diagnosis and better management by innovating new therapeutic targets. In this study, we aimed to detect the association between CD4+CD8+FOX3+ Tregs, T1DM, and associated cardiovascular complications. The study included 144 individuals divided into three groups, group 1 included 48 patients suffering from T1DM without cardiovascular complications, group II: included 48 type T1DM patients with cardiovascular complications. Group III: included 48 healthy control subjects. For all participants, markers for inflammation, and cardiovascular involvement were assessed. The percentage of CD4+ CD25+ FOXP3+ Regulatory T- cells (Tregs) was measured by flow cytometry using peripheral blood samples. The level of Treg was lowest in group II and highest in group III, the difference was highly significant P < 0.001. Treg in group I significantly correlated with age (r= 0.58, P=0.004), CK-mb (r= 0.61, P=0.04) and LDL (r= -.61, P=0.4). While in group II, it correlated with triglyceride level, (r= 0.65 and a P =- 0.02). In conclusion, Lower levels of Tregs are associated with cardiovascular complications in TIDM patients.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Cardiovasculares / Linfocitos T Reguladores / Diabetes Mellitus Tipo 1 Tipo de estudio: Observational_studies / Risk_factors_studies / Screening_studies Límite: Humans Idioma: En Revista: Egypt J Immunol Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2019 Tipo del documento: Article País de afiliación: Egipto Pais de publicación: Egipto
Buscar en Google
Añadir a Mi BVS
Imprimir
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PubMed Links

Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Cardiovasculares / Linfocitos T Reguladores / Diabetes Mellitus Tipo 1 Tipo de estudio: Observational_studies / Risk_factors_studies / Screening_studies Límite: Humans Idioma: En Revista: Egypt J Immunol Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2019 Tipo del documento: Article País de afiliación: Egipto Pais de publicación: Egipto