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High proportion of coxsackievirus B3 genotype A in hand, foot and mouth disease in Zhenjiang, China, 2011-2016.
Fu, Xuemin; Mao, Lingxiang; Wan, Zhenzhou; Xu, Rong; Ma, Yingying; Shen, Li; Jin, Xia; Zhang, Chiyu.
Afiliación
  • Fu X; Pathogen Discovery and Big Data Center, CAS Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China. Electronic address: shirleymin.fu@outlook.com.
  • Mao L; Department of Clinical Laboratory, Affiliated People's Hospital, Jiangsu University, Zhenjiang, China. Electronic address: maolingxiang@aliyun.com.
  • Wan Z; Medical Laboratory of Taizhou Fourth People's Hospital, Taizhou, China. Electronic address: wanlv@126.com.
  • Xu R; Pathogen Discovery and Big Data Center, CAS Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China. Electronic address: rxu@ips.ac.cn.
  • Ma Y; Pathogen Discovery and Big Data Center, CAS Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China. Electronic address: yyma@ips.ac.cn.
  • Shen L; Zhenjiang Center of Disease Control and Prevention, Jiuhuangshan South Road, Zhenjiang, China. Electronic address: snowforest1982@163.com.
  • Jin X; Viral Disease and Vaccine Translational Research Unit, CAS Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai 200031, China. Electronic address: xjin@ips.ac.cn.
  • Zhang C; Pathogen Discovery and Big Data Center, CAS Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China. Electronic address: zhangcy1999@ips.ac.cn.
Int J Infect Dis ; 87: 1-7, 2019 Oct.
Article en En | MEDLINE | ID: mdl-31330324
BACKGROUND: Hand, foot and mouth disease (HFMD) is usually caused by EVA71 and CVA16 except for a few cases that are caused by non-EVA71 non-CAV16 enteroviruses. Coxsackievirus B3 (CVB3) is mostly associated with myocarditis, occasionally with HFMD. METHODS: The partial VP1 gene of enteroviruses were amplified and sequenced from 610 throat swabs from clinically confirmed HFMD children. All available CVB3 near full-length genomic and VP1 sequences were downloaded from GenBank. Phylogenetic and distance analyses were performed using MEGA 7.0. RESULTS: A total of 238 partial VP1 sequences were obtained, including 93 EVA71 (39%), 79 CAV16 (33%), 29 CVB3 (12%), 24 CVA6 (10%), and 13 other enterovirus serotypes (5.5%). CVB3 is classified into seven genotypes A-G according to phylogenetic and distance analyses. All CVB3 strains from Zhenjiang belonged to genotype A. In contrast to other genotypes that are prevalent in Europe and other regions of China, and often associated with aseptic meningitis and myocarditis, CVB3 genotype A strains identified in Zhenjiang were only detected among HFMD patients. CONCLUSIONS: This high prevalence of CVB3 genotype A among HFMD children has never been reported. This phenomenon has revealed a new epidemic trend of CVB3 among HFMD in China, and it has epidemiological implications for monitoring the epidemic risk of CVB3.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enterovirus Humano A / Enfermedad de Boca, Mano y Pie Tipo de estudio: Prevalence_studies / Risk_factors_studies Límite: Child / Child, preschool / Female / Humans / Infant / Male País/Región como asunto: Asia / Europa Idioma: En Revista: Int J Infect Dis Asunto de la revista: DOENCAS TRANSMISSIVEIS Año: 2019 Tipo del documento: Article Pais de publicación: Canadá
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enterovirus Humano A / Enfermedad de Boca, Mano y Pie Tipo de estudio: Prevalence_studies / Risk_factors_studies Límite: Child / Child, preschool / Female / Humans / Infant / Male País/Región como asunto: Asia / Europa Idioma: En Revista: Int J Infect Dis Asunto de la revista: DOENCAS TRANSMISSIVEIS Año: 2019 Tipo del documento: Article Pais de publicación: Canadá