Your browser doesn't support javascript.
loading
Beyond sleepy: structural and functional changes of the default-mode network in idiopathic hypersomnia.
Pomares, Florence B; Boucetta, Soufiane; Lachapelle, Francis; Steffener, Jason; Montplaisir, Jacques; Cha, Jungho; Kim, Hosung; Dang-Vu, Thien Thanh.
Afiliación
  • Pomares FB; Center for Studies in Behavioral Neurobiology and Department of Health, Kinesiology and Applied Physiology, Concordia University, Montreal, QC, Canada.
  • Boucetta S; PERFORM Centre, Concordia University, Montreal, QC, Canada.
  • Lachapelle F; Centre de Recherche de l'Institut Universitaire de Gériatrie de Montréal, Montreal, QC, Canada.
  • Steffener J; Center for Advanced Research in Sleep Medicine, Hôpital du Sacré-Coeur de Montréal, Montreal, QC, Canada.
  • Montplaisir J; Center for Studies in Behavioral Neurobiology and Department of Health, Kinesiology and Applied Physiology, Concordia University, Montreal, QC, Canada.
  • Cha J; PERFORM Centre, Concordia University, Montreal, QC, Canada.
  • Kim H; Centre de Recherche de l'Institut Universitaire de Gériatrie de Montréal, Montreal, QC, Canada.
  • Dang-Vu TT; Interdisciplinary School of Health Science, University of Ottawa, Ottawa, ON, Canada.
Sleep ; 42(11)2019 10 21.
Article en En | MEDLINE | ID: mdl-31328786
Idiopathic hypersomnia (IH) is characterized by excessive daytime sleepiness but, in contrast to narcolepsy, does not involve cataplexy, sleep-onset REM periods, or any consistent hypocretin-1 deficiency. The pathophysiological mechanisms of IH remain unclear. Because of the involvement of the default-mode network (DMN) in alertness and sleep, our aim was to investigate the structural and functional modifications of the DMN in IH. We conducted multimodal magnetic resonance imaging (MRI) in 12 participants with IH and 15 good sleeper controls (mean age ± SD: 32 ± 9.6 years, range 22-53 years, nine males). Self-reported as well as objective measures of daytime sleepiness were collected. Gray matter volume and cortical thickness were analyzed to investigate brain structural differences between good sleepers and IH. Structural covariance and resting-state functional connectivity were analyzed to investigate changes in the DMN. Participants with IH had greater volume and cortical thickness in the precuneus, a posterior hub of the DMN. Cortical thickness in the left medial prefrontal cortex was positively correlated with thickness of the precuneus, and the strength of this correlation was greater in IH. In contrast, functional connectivity at rest was lower within the anterior DMN (medial prefrontal cortex) in IH, and correlated with self-reported daytime sleepiness. The present results show that IH is associated with structural and functional differences in the DMN, in proportion to the severity of daytime sleepiness, suggesting that a disruption of the DMN contributes to the clinical features of IH. Larger volume and thickness in this network might reflect compensatory changes to lower functional connectivity in IH.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Encéfalo / Hipersomnia Idiopática / Red Nerviosa Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Sleep Año: 2019 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Encéfalo / Hipersomnia Idiopática / Red Nerviosa Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Sleep Año: 2019 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Estados Unidos