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Immunogenicity of the pneumococcal non-typeable Haemophilus influenzae protein D conjugate vaccine (PHiD-CV) administered concomitantly with the meningococcal serogroup B (4CMenB) vaccine in infants: A post-hoc analysis in a phase 3b, randomised, controlled trial.
Safadi, Marco Aurelio P; Martinon-Torres, Federico; Weckx, Lily Yin; Moreira, Edson Duarte; da Fonseca Lima, Eduardo Jorge; Willemsen, Arnold; Toneatto, Daniela; Habib, Md Ahsan; Borys, Dorota.
Afiliación
  • Safadi MAP; Santa Casa de São Paulo School of Medical Sciences and CDEC, São Paulo, Brazil. Electronic address: masafadi@uol.com.br.
  • Martinon-Torres F; Hospital Clinico Universitario de Santiago de Compostela, Santiago de Compostela, Spain; Genetics, Vaccines and Pediatrics Research Group (GENVIP), Instituto de Investigación Sanitaria de Santiago, University of Santiago de Compostela, Spain. Electronic address: federico.martinon.torres@sergas.es.
  • Weckx LY; Federal University of Sao Paulo, Brazil. Electronic address: lily.crie@huhsp.org.br.
  • Moreira ED; CPEC - Associação Obras Sociais Irma Dulce and Oswaldo Cruz Foundation, Brazilian Ministry of Health, Salvador, Brazil. Electronic address: edson@bahia.fiocruz.br.
  • da Fonseca Lima EJ; CPEC - Instituto de Medicina Integral Professor Fernando Figueira, Boa Vista Recife, PE, Brazil. Electronic address: eduardojorge@imip.org.br.
  • Willemsen A; Plus100 B.V. c/o Biostatistics, GSK, Amsterdam, the Netherlands. Electronic address: arnold.x.willemsen@gsk.com.
  • Toneatto D; GSK, Siena, Italy. Electronic address: daniela.x.toneatto@gsk.com.
  • Habib MA; GSK, Wavre, Belgium. Electronic address: ahsan.m.habib@gsk.com.
  • Borys D; GSK, Wavre, Belgium. Electronic address: dorota.d.borys@gsk.com.
Vaccine ; 37(35): 4858-4863, 2019 08 14.
Article en En | MEDLINE | ID: mdl-31327652
BACKGROUND: No data are currently available on immunogenicity of higher-valent pneumococcal conjugate vaccines when co-administered with a 4-component meningococcal serogroup B vaccine (4CMenB). METHODS: Post-hoc analysis of pneumococcal non-typeable Haemophilus influenzae protein D conjugate vaccine (PHiD-CV) immunogenicity when co-administered with 4CMenB (2 + 1 schedule) and/or a CRM-conjugated meningococcal serogroup C vaccine (MenC-CRM) in a trial assessing 4CMenB reduced schedules and co-administration with MenC-CRM (NCT01339923). Infants were randomized to receive 4CMenB and MenC-CRM (Group 1) or MenC-CRM (Group 2) at 3, 5, and 12 months (M) of age. Both groups received PHiD-CV (3 + 1 schedule) as part of the Brazilian national immunisation programme at 3 M, 5 M, 7 M, and 12 M of age. Antibody responses were assessed pre-vaccination, 1 M post-dose 2, pre-booster, and 1 M post-booster. RESULTS: Anti-pneumococcal antibody responses were in similar ranges in the two study groups. CONCLUSIONS: 4CMenB co-administration did not seem to impact antibody responses to PHiD-CV in infants.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones Neumocócicas / Vacunas Meningococicas / Vacunas Neumococicas / Inmunogenicidad Vacunal Tipo de estudio: Clinical_trials Límite: Female / Humans / Infant / Male País/Región como asunto: America do sul / Brasil Idioma: En Revista: Vaccine Año: 2019 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
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Imprimir
XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones Neumocócicas / Vacunas Meningococicas / Vacunas Neumococicas / Inmunogenicidad Vacunal Tipo de estudio: Clinical_trials Límite: Female / Humans / Infant / Male País/Región como asunto: America do sul / Brasil Idioma: En Revista: Vaccine Año: 2019 Tipo del documento: Article Pais de publicación: Países Bajos