Endocannabinoids and endocannabinoid-like compounds modulate hypoxia-induced permeability in CaCo-2 cells via CB<sub>1</sub>, TRPV1, and PPAR&#945;.

Karwad, M A; Couch, D G; Wright, K L; Tufarelli, C; Larvin, M; Lund, J; O'Sullivan, S E

Endocannabinoids and endocannabinoid-like compounds modulate hypoxia-induced permeability in CaCo-2 cells via CB₁, TRPV1, and PPARα.

Karwad, M A; Couch, D G; Wright, K L; Tufarelli, C; Larvin, M; Lund, J; O'Sullivan, S E.

Afiliación

Karwad MA; Division of Medical Sciences & Graduate Entry Medicine, School of Medicine, Royal Derby Hospital, University of Nottingham, Nottingham, UK.
Couch DG; Division of Medical Sciences & Graduate Entry Medicine, School of Medicine, Royal Derby Hospital, University of Nottingham, Nottingham, UK.
Wright KL; Division of Biomedical & Life Sciences, Faculty of Health & Medicine, Lancaster University, Lancaster, UK.
Tufarelli C; Leicester Cancer Research Centre, Department of Genetics and Genome Biology, University of Leicester, Leicester, UK.
Larvin M; Graduate Entry Medical School and Health Research Institute, University of Limerick, Limerick, Ireland.
Lund J; Division of Medical Sciences & Graduate Entry Medicine, School of Medicine, Royal Derby Hospital, University of Nottingham, Nottingham, UK.
O'Sullivan SE; Division of Medical Sciences & Graduate Entry Medicine, School of Medicine, Royal Derby Hospital, University of Nottingham, Nottingham, UK. Electronic address: Saoirse.osullivan@nottingham.ac.uk.

Biochem Pharmacol ; 168: 465-472, 2019 10.

Article en En | MEDLINE | ID: mdl-31325449

Asunto(s)

Permeabilidad de la Membrana Celular/efectos de los fármacos; Endocannabinoides/metabolismo; PPAR alfa/metabolismo; Receptor Cannabinoide CB1/metabolismo; Canales Catiónicos TRPV/metabolismo; Células CACO-2; Hipoxia de la Célula/efectos de los fármacos; Hipoxia de la Célula/fisiología; Permeabilidad de la Membrana Celular/fisiología; Endocannabinoides/farmacología; Humanos; Receptor Cannabinoide CB1/agonistas; Migración Transendotelial y Transepitelial/efectos de los fármacos; Migración Transendotelial y Transepitelial/fisiología

Palabras clave

2-Arachidonoylglycerol (2-AG); Anandamide (AEA); Caco-2 cells; Cannabinoid receptor 1 (CB(1)); Cannabinoid receptors; Endocannabinoids; Hypoxia; Intestinal permeability; Ischaemia; N-arachidonoyl-dopamine (NADA); Noladin ether (NE); Oleamide (OA); Peroxisome proliferator-activated receptor alpha (PPARα); Transepithelial electrical resistance (TEER); Transient receptor potential vanilloid subtype 1 (TRPV1); Virodhamine (VD)

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Permeabilidad de la Membrana Celular / Receptor Cannabinoide CB1 / Endocannabinoides / PPAR alfa / Canales Catiónicos TRPV Límite: Humans Idioma: En Revista: Biochem Pharmacol Año: 2019 Tipo del documento: Article País de afiliación: Reino Unido Pais de publicación: Reino Unido

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google