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Multi-residue analysis using liquid chromatography tandem mass spectrometry for detection of 20 coccidiostats in poultry, livestock, and aquatic tissues.
Chang, Shun-Hsien; Lai, Yu-Hsun; Huang, Chih-Neng; Peng, Guan-Jhih; Liao, Chia-Ding; Kao, Ya-Min; Tseng, Su-Hsiang; Wang, Der-Yuan.
Afiliación
  • Chang SH; Food and Drug Administration, Ministry of Health and Welfare, Executive Yuan, 161-2 Kunyang St., Nangang Dist., Taipei City 11561, Taiwan.
  • Lai YH; Food and Drug Administration, Ministry of Health and Welfare, Executive Yuan, 161-2 Kunyang St., Nangang Dist., Taipei City 11561, Taiwan.
  • Huang CN; Food and Drug Administration, Ministry of Health and Welfare, Executive Yuan, 161-2 Kunyang St., Nangang Dist., Taipei City 11561, Taiwan.
  • Peng GJ; Food and Drug Administration, Ministry of Health and Welfare, Executive Yuan, 161-2 Kunyang St., Nangang Dist., Taipei City 11561, Taiwan.
  • Liao CD; Food and Drug Administration, Ministry of Health and Welfare, Executive Yuan, 161-2 Kunyang St., Nangang Dist., Taipei City 11561, Taiwan.
  • Kao YM; Food and Drug Administration, Ministry of Health and Welfare, Executive Yuan, 161-2 Kunyang St., Nangang Dist., Taipei City 11561, Taiwan.
  • Tseng SH; Food and Drug Administration, Ministry of Health and Welfare, Executive Yuan, 161-2 Kunyang St., Nangang Dist., Taipei City 11561, Taiwan.
  • Wang DY; Food and Drug Administration, Ministry of Health and Welfare, Executive Yuan, 161-2 Kunyang St., Nangang Dist., Taipei City 11561, Taiwan.
J Food Drug Anal ; 27(3): 703-716, 2019 07.
Article en En | MEDLINE | ID: mdl-31324286
In this study, we developed a novel analysis method based on liquid chromatography/tandem mass spectrometry (LC-MS/MS) to allow the simultaneous identification of 20 coccidiostats in eight matrix categories, including the muscles of chicken, swine, cow, and fish as well as chicken eggs, bovine milk, and porcine viscera. In the pretreatment procedure, acetonitrile/methanol (95:5, v/v) containing 1% formic acid, 5 g of sodium acetate, and 6.0 g of anhydrous magnesium sulfate was used for extraction, followed by a clean-up procedure using n-hexane saturated with ACN to facilitate the elimination of analytes from high lipid samples. Chromatographic separations were achieved using a Poroshell 120SB C18 column and operated with a gradient mobile phase system consisting of methanol (with 0.1% formic acid) and 5 mM ammonium formate, and the MS detection was monitored simultaneously. The method was validated in accordance with the Guidelines for the Validation of Food Chemical Methods by the Taiwan Food and Drug Administration. The limit of quantitation among 8 matrices were 0.5-2 ng g-1. The proposed method proved highly effective in detecting the presence of targeted veterinary drugs, providing a high degree of precision and accuracy over a broad range of matrices.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Coccidiostáticos Tipo de estudio: Diagnostic_studies Límite: Animals Idioma: En Revista: J Food Drug Anal Año: 2019 Tipo del documento: Article País de afiliación: Taiwán Pais de publicación: China
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Coccidiostáticos Tipo de estudio: Diagnostic_studies Límite: Animals Idioma: En Revista: J Food Drug Anal Año: 2019 Tipo del documento: Article País de afiliación: Taiwán Pais de publicación: China