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Reduced sensory-evoked structural plasticity in the aging barrel cortex.
Voglewede, Rebecca L; Vandemark, Kaeli M; Davidson, Andrew M; DeWitt, Annie R; Heffler, Marissa D; Trimmer, Emma H; Mostany, Ricardo.
Afiliación
  • Voglewede RL; Neuroscience Program, Tulane University School of Science and Engineering, New Orleans, LA, USA; Tulane Brain Institute, Tulane University, New Orleans, LA, USA; Department of Pharmacology, Tulane University School of Medicine, New Orleans, LA, USA.
  • Vandemark KM; Neuroscience Program, Tulane University School of Science and Engineering, New Orleans, LA, USA; Tulane Brain Institute, Tulane University, New Orleans, LA, USA.
  • Davidson AM; Department of Pharmacology, Tulane University School of Medicine, New Orleans, LA, USA; Department of Cell and Molecular Biology, Tulane University School of Science and Engineering, New Orleans, LA, USA.
  • DeWitt AR; Neuroscience Program, Tulane University School of Science and Engineering, New Orleans, LA, USA; Tulane Brain Institute, Tulane University, New Orleans, LA, USA.
  • Heffler MD; Neuroscience Program, Tulane University School of Science and Engineering, New Orleans, LA, USA; Tulane Brain Institute, Tulane University, New Orleans, LA, USA; Department of Biomedical Engineering, Tulane University School of Science and Engineering, Lindy Boggs Center Suite 500, New Orleans, LA,
  • Trimmer EH; Department of Pharmacology, Tulane University School of Medicine, New Orleans, LA, USA.
  • Mostany R; Neuroscience Program, Tulane University School of Science and Engineering, New Orleans, LA, USA; Tulane Brain Institute, Tulane University, New Orleans, LA, USA; Department of Pharmacology, Tulane University School of Medicine, New Orleans, LA, USA. Electronic address: rmostany@tulane.edu.
Neurobiol Aging ; 81: 222-233, 2019 09.
Article en En | MEDLINE | ID: mdl-31323444
Impairments in synaptic connectivity have been linked to cognitive deficits in age-related neurodegenerative disorders and healthy aging. However, the anatomical and structural bases of these impairments have not been identified yet. A hallmark of neural plasticity in young adults is short-term synaptic rearrangement, yet aged animals already display higher synaptic turnover rates at the baseline. Using two-photon excitation (2PE) microscopy, we explored if this elevated turnover alters the aged brain's response to plasticity. Following a sensory-evoked plasticity protocol involving whisker stimulation, aged mice display reduced spine dynamics (gain, loss, and turnover), decreased spine clustering, and lower spine stability when compared to young adult mice. These results suggest a deficiency of the cortical neurons of aged mice to structurally incorporate new sensory experiences, in the form of clustered, long-lasting synapses, into already existing cortical circuits. This research provides the first evidence linking experience-dependent plasticity with in vivo spine dynamics in the aged brain and supports a model of both reduced synaptic plasticity and reduced synaptic tenacity in the aged somatosensory system.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Corteza Somatosensorial / Envejecimiento / Espinas Dendríticas / Plasticidad Neuronal Tipo de estudio: Etiology_studies Límite: Animals Idioma: En Revista: Neurobiol Aging Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Corteza Somatosensorial / Envejecimiento / Espinas Dendríticas / Plasticidad Neuronal Tipo de estudio: Etiology_studies Límite: Animals Idioma: En Revista: Neurobiol Aging Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos