MTTP polymorphisms and hepatic steatosis in individuals chronically infected with hepatitis C virus.
Arch Virol
; 164(10): 2559-2563, 2019 Oct.
Article
en En
| MEDLINE
| ID: mdl-31321587
Polymorphisms in the microsomal triglyceride transfer protein (MTTP) gene were genotyped in individuals who were chronically infected with hepatitis C virus (HCV). In the 236 patients, the frequencies of risk alleles of the -164T/C (rs1800804), -400A/T (rs1800803) and H297Q (rs2306985) polymorphisms were 0.30, 0.41 and 0.50, respectively. A significant association between the risk alleles of the -164T/C and -400A/T polymorphisms combined with HCV genotype 3 infection and the occurrence of steatosis was detected (p = 0.004 and p = 0.032), suggesting that a combination of host and viral factors can potentially be used to predict hepatic steatosis.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Proteínas Portadoras
/
Hepacivirus
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Hepatitis C Crónica
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Predisposición Genética a la Enfermedad
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Hígado Graso
Tipo de estudio:
Prognostic_studies
Límite:
Adult
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Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Arch Virol
Año:
2019
Tipo del documento:
Article
País de afiliación:
Brasil
Pais de publicación:
Austria