Your browser doesn't support javascript.
loading
Preparation of injectable temperature-sensitive chitosan-based hydrogel for combined hyperthermia and chemotherapy of colon cancer.
Zheng, Yuting; Wang, Weifan; Zhao, Jiulong; Wu, Chenyao; Ye, Changqing; Huang, Mingxian; Wang, Shige.
Afiliación
  • Zheng Y; College of Science, University of Shanghai for Science and Technology, No. 334 Jungong Road, Shanghai, 200093, China.
  • Wang W; Department of Allergy and Immunology, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, No. 1678 Dongfang Road, Shanghai, 200127, China.
  • Zhao J; Department of Gastroenterology, Changhai Hospital, Second Military Medical University, No. 168 Dongfang Road, Shanghai, 200433, China.
  • Wu C; College of Science, University of Shanghai for Science and Technology, No. 334 Jungong Road, Shanghai, 200093, China.
  • Ye C; College of Science, University of Shanghai for Science and Technology, No. 334 Jungong Road, Shanghai, 200093, China.
  • Huang M; College of Science, University of Shanghai for Science and Technology, No. 334 Jungong Road, Shanghai, 200093, China.
  • Wang S; College of Science, University of Shanghai for Science and Technology, No. 334 Jungong Road, Shanghai, 200093, China. Electronic address: sgwang@usst.edu.cn.
Carbohydr Polym ; 222: 115039, 2019 Oct 15.
Article en En | MEDLINE | ID: mdl-31320053
The purpose of this study was to design an injectable hydrogel with temperature-sensitive property for safe and high efficient in vivo colon cancer hyperthermia and chemotherapy. Chitosan (CS) solution was injected into the tumor at room temperature and automatically gelled after warming to body temperature in the present of ß-glycerophosphate (ß-GP). Combined localized tumor photothermal and chemotherapy were achieved by dissolving photothermal material MoS2/Bi2S3-PEG (MBP) nanosheets and drug molecule doxorubicin (DOX) into the hydrogel, and the gel system could encapsulate DOX and MBP nanosheets and prevent them from entering the blood circulation and damaging normal tissues and cells. More importantly, the CS/MBP/DOX (CMD) hydrogel exhibited a photothermal efficiency of 22.18% and 31.42% in the first and second near infrared light (NIR I and NIR II) biowindows respectively at a low MBP concentration (0.5 mg/mL). Besides, the release of the DOX from CMD hydrogel was controllable since the gel temperature could be governed by NIR laser irradiation. Moreover, the chitosan-based hydrogel had antibacterial effects. The designed composite hydrogel is anticipated to act as a platform for the high efficient treatment of tumors owing to the different penetration depths of NIR I and NIR II.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Portadores de Fármacos / Doxorrubicina / Neoplasias del Colon / Hidrogeles / Quitosano / Antineoplásicos Tipo de estudio: Diagnostic_studies Límite: Animals Idioma: En Revista: Carbohydr Polym Año: 2019 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Portadores de Fármacos / Doxorrubicina / Neoplasias del Colon / Hidrogeles / Quitosano / Antineoplásicos Tipo de estudio: Diagnostic_studies Límite: Animals Idioma: En Revista: Carbohydr Polym Año: 2019 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido