Effects of Nitroglycerine on Renal Ischemia-Reperfusion Injury in Adult Male Rats.
Drug Res (Stuttg)
; 69(11): 612-620, 2019 Oct.
Article
en En
| MEDLINE
| ID: mdl-31315134
BACKGROUND: Ischemia-reperfusion (I-R) leads to acute kidney injury (AKI). The present study investigated the effects of nitroglycerine (NG) on improving renal dysfunctions caused by I-R in rats. METHODOLOGY: Twenty-four rats were equally divided into four groups: (1) the control group, (2) the sham group, (3) the I-R group, and (4) NG-treated groups.NG (50 µg/kg) was injected intraperitoneally after induction of IR. I-R was induced through clamping of the bilateral renal artery and vein of both kidneys for 20 min followed by 24 h of reperfusion. RESULTS: NG significantly increased the creatinine clearance levels and renal blood flow rate (which was reduced by I-R). NG also significantly improved serum electrolytes (sodium and potassium) that were disordered by I-R. In addition, NG significantly offset impaired antioxidant defense mechanism and inhibited lipid peroxidation. CONCLUSIONS: The results show NG has a protective effect on renal tissue against AKI caused by I-R. These protective effects mediated through antioxidant activity and decrease of lipid peroxidation.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Daño por Reperfusión
/
Nitroglicerina
/
Riñón
Límite:
Animals
Idioma:
En
Revista:
Drug Res (Stuttg)
Año:
2019
Tipo del documento:
Article
País de afiliación:
Irán
Pais de publicación:
Alemania