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Cordycepin improves behavioral-LTP and dendritic structure in hippocampal CA1 area of rats.
Han, Yuan-Yuan; Chen, Zhao-Hui; Shang, Ying-Jie; Yan, Wen-Wen; Wu, Bao-Yan; Li, Chu-Hua.
Afiliación
  • Han YY; School of Life Science, South China Normal University, Guangzhou, China.
  • Chen ZH; School of Life Science, South China Normal University, Guangzhou, China.
  • Shang YJ; School of Life Science, South China Normal University, Guangzhou, China.
  • Yan WW; School of Life Science, South China Normal University, Guangzhou, China.
  • Wu BY; MOE Key Laboratory of Laser Life Science & Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou, China.
  • Li CH; School of Life Science, South China Normal University, Guangzhou, China.
J Neurochem ; 151(1): 79-90, 2019 10.
Article en En | MEDLINE | ID: mdl-31314908
Cordycepin, an adenosine analog, has been reported to improve cognitive function, but which seems to be inconsistent with the reports showing that cordycepin inhibited long-term potentiation (LTP). Behavioral-LTP is usually used to study long-term synaptic plasticity induced by learning tasks in freely moving animals. In order to investigate simultaneously the effects of cordycepin on LTP and behavior in rats, we applied the model of behavioral-LTP induced by Y-maze learning task through recording population spikes in hippocampal CA1 region. Golgi staining and Sholl analysis were employed to assess the morphological structure of dendrites in pyramidal cells of hippocampal CA1 area, and western blotting was used to examine the level of adenosine A1 receptors and A2A receptors (A2AR). We found that cordycepin significantly improved behavioral-LTP magnitude, accompanied by increases in the total length of dendrites, the number of intersections and spine density but did not affect Y-maze learning task. Furthermore, cordycepin obviously reduced A2AR level without altering adenosine A1 receptors level; and the agonist of A2AR (CGS 21680) rather than antagonist (SCH 58261) could reverse the potentiation of behavioral-LTP induced by cordycepin. These results suggested that cordycepin improved behavioral-LTP and morphological structure of dendrite in hippocampal CA1 but did not contribute to the improvement of learning and memory. And cordycepin improved behavioral-LTP may be through reducing the level of A2AR in hippocampus. Collectively, the effects of cordycepin on cognitive function and LTP were complex and involved multiple mechanisms.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Desoxiadenosinas / Potenciación a Largo Plazo / Aprendizaje por Laberinto / Dendritas / Región CA1 Hipocampal Límite: Animals Idioma: En Revista: J Neurochem Año: 2019 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Desoxiadenosinas / Potenciación a Largo Plazo / Aprendizaje por Laberinto / Dendritas / Región CA1 Hipocampal Límite: Animals Idioma: En Revista: J Neurochem Año: 2019 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido