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Microinvasion by Streptococcus pneumoniae induces epithelial innate immunity during colonisation at the human mucosal surface.
Weight, Caroline M; Venturini, Cristina; Pojar, Sherin; Jochems, Simon P; Reiné, Jesús; Nikolaou, Elissavet; Solórzano, Carla; Noursadeghi, Mahdad; Brown, Jeremy S; Ferreira, Daniela M; Heyderman, Robert S.
Afiliación
  • Weight CM; Division of Infection and Immunity, University College London, London, UK. c.weight@ucl.ac.uk.
  • Venturini C; Division of Infection and Immunity, University College London, London, UK.
  • Pojar S; Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, UK.
  • Jochems SP; Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, UK.
  • Reiné J; Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, UK.
  • Nikolaou E; Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, UK.
  • Solórzano C; Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, UK.
  • Noursadeghi M; Division of Infection and Immunity, University College London, London, UK.
  • Brown JS; Department of Respiratory Medicine, University College London, London, UK.
  • Ferreira DM; Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, UK.
  • Heyderman RS; Division of Infection and Immunity, University College London, London, UK.
Nat Commun ; 10(1): 3060, 2019 07 16.
Article en En | MEDLINE | ID: mdl-31311921
Control of Streptococcus pneumoniae colonisation at human mucosal surfaces is critical to reducing the burden of pneumonia and invasive pneumococcal disease, interrupting transmission, and achieving herd protection. Here, we use an experimental human pneumococcal carriage model (EHPC) to show that S. pneumoniae colonisation is associated with epithelial surface adherence, micro-colony formation and invasion, without overt disease. Interactions between different strains and the epithelium shaped the host transcriptomic response in vitro. Using epithelial modules from a human epithelial cell model that recapitulates our in vivo findings, comprising of innate signalling and regulatory pathways, inflammatory mediators, cellular metabolism and stress response genes, we find that inflammation in the EHPC model is most prominent around the time of bacterial clearance. Our results indicate that, rather than being confined to the epithelial surface and the overlying mucus layer, the pneumococcus undergoes micro-invasion of the epithelium that enhances inflammatory and innate immune responses associated with clearance.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones Neumocócicas / Streptococcus pneumoniae / Portador Sano / Nasofaringe / Mucosa Respiratoria Tipo de estudio: Prognostic_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2019 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones Neumocócicas / Streptococcus pneumoniae / Portador Sano / Nasofaringe / Mucosa Respiratoria Tipo de estudio: Prognostic_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2019 Tipo del documento: Article Pais de publicación: Reino Unido