Genome-wide mutagenesis resulting from topoisomerase 1-processing of unrepaired ribonucleotides in DNA.

Williams, Jessica S; Lujan, Scott A; Zhou, Zhi-Xiong; Burkholder, Adam B; Clark, Alan B; Fargo, David C; Kunkel, Thomas A

Williams, Jessica S; Lujan, Scott A; Zhou, Zhi-Xiong; Burkholder, Adam B; Clark, Alan B; Fargo, David C; Kunkel, Thomas A.

Afiliación

Williams JS; Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, US National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC, USA.
Lujan SA; Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, US National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC, USA.
Zhou ZX; Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, US National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC, USA.
Burkholder AB; Integrative Bioinformatics Support Group, National Institute of Environmental Health Sciences, US National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC, USA.
Clark AB; Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, US National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC, USA.
Fargo DC; Integrative Bioinformatics Support Group, National Institute of Environmental Health Sciences, US National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC, USA.
Kunkel TA; Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, US National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC, USA. Electronic address: kunkel@niehs.nih.gov.

DNA Repair (Amst) ; 84: 102641, 2019 12.

Article en En | MEDLINE | ID: mdl-31311768

Asunto(s)

Reparación del ADN; ADN-Topoisomerasas de Tipo I/metabolismo; Tasa de Mutación; Ribonucleótidos/genética; Proteínas de Saccharomyces cerevisiae/metabolismo; ADN-Topoisomerasas de Tipo I/genética; ADN Polimerasa Dirigida por ADN/metabolismo; Repeticiones de Dinucleótido; Eliminación de Gen; Inestabilidad Genómica; Saccharomyces cerevisiae; Proteínas de Saccharomyces cerevisiae/genética; Repeticiones de Trinucleótidos

Palabras clave

DNA polymerase; Deletion mutations; Muver; Ribonucleotide excision repair; Topoisomerase 1; Whole-genome sequencing

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ribonucleótidos / ADN-Topoisomerasas de Tipo I / Proteínas de Saccharomyces cerevisiae / Reparación del ADN / Tasa de Mutación Idioma: En Revista: DNA Repair (Amst) Asunto de la revista: BIOLOGIA MOLECULAR / BIOQUIMICA Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Países Bajos

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