Repurposing Quinacrine against Ebola Virus Infection <i>In Vivo</i>.

Lane, Thomas R; Comer, Jason E; Freiberg, Alexander N; Madrid, Peter B; Ekins, Sean

Repurposing Quinacrine against Ebola Virus Infection In Vivo.

Lane, Thomas R; Comer, Jason E; Freiberg, Alexander N; Madrid, Peter B; Ekins, Sean.

Afiliación

Lane TR; Collaborations Pharmaceuticals, Inc., Raleigh, North Carolina, USA.
Comer JE; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, USA.
Freiberg AN; Institutional Office of Regulated Nonclinical Studies, University of Texas Medical Branch, Galveston, Texas, USA.
Madrid PB; Department of Pathology, University of Texas Medical Branch, Galveston, Texas, USA.
Ekins S; Department of Pathology, University of Texas Medical Branch, Galveston, Texas, USA.

Antimicrob Agents Chemother ; 63(9)2019 09.

Article en En | MEDLINE | ID: mdl-31307979

RESUMEN

Quinacrine hydrochloride is a small-molecule, orally bioavailable drug that has been used clinically as an antimalarial and for many other applications. A machine learning model trained on Ebola virus (EBOV) screening data identified quinacrine as a potent (nanomolar) in vitro inhibitor. In the current study, quinacrine 25 mg/kg was shown to protect 70% of mice (statistically significant) from a lethal challenge with mouse-adapted EBOV with once-daily intraperitoneal dosing for 8 days.

Asunto(s)

Antimaláricos/farmacología; Antivirales/farmacología; Reposicionamiento de Medicamentos; Ebolavirus/efectos de los fármacos; Fiebre Hemorrágica Ebola/tratamiento farmacológico; Quinacrina/farmacología; Animales; Células CACO-2; Chlorocebus aethiops; Modelos Animales de Enfermedad; Ebolavirus/crecimiento & desarrollo; Células HeLa; Fiebre Hemorrágica Ebola/mortalidad; Fiebre Hemorrágica Ebola/patología; Fiebre Hemorrágica Ebola/virología; Humanos; Ratones; Ratones Endogámicos BALB C; Pruebas de Sensibilidad Microbiana; Análisis de Supervivencia; Tilorona/farmacología; Células Vero; Carga Viral/efectos de los fármacos

Palabras clave

Ebola virus; Ebola virus disease; antiviral; quinacrine

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Antivirales / Quinacrina / Fiebre Hemorrágica Ebola / Ebolavirus / Reposicionamiento de Medicamentos / Antimaláricos Límite: Animals / Humans Idioma: En Revista: Antimicrob Agents Chemother Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos

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