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Design of a brain-penetrant CDK4/6 inhibitor for glioblastoma.
Bronner, Sarah M; Merrick, Karl A; Murray, Jeremy; Salphati, Laurent; Moffat, John G; Pang, Jodie; Sneeringer, Christopher J; Dompe, Nicholas; Cyr, Patrick; Purkey, Hans; Boenig, Gladys de Leon; Li, Jun; Kolesnikov, Aleksandr; Larouche-Gauthier, Robin; Lai, Kwong Wah; Shen, Xiaoli; Aubert-Nicol, Samuel; Chen, Yi-Chen; Cheong, Jonathan; Crawford, James J; Hafner, Marc; Haghshenas, Pouyan; Jakalian, Araz; Leclerc, Jean-Philippe; Lim, Ngiap-Kie; O'Brien, Tom; Plise, Emile G; Shalan, Hadil; Sturino, Claudio; Wai, John; Xiao, Yang; Yin, Jianping; Zhao, Liang; Gould, Stephen; Olivero, Alan; Heffron, Timothy P.
Afiliación
  • Bronner SM; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, United States. Electronic address: sbronner@mazetx.com.
  • Merrick KA; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, United States.
  • Murray J; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, United States.
  • Salphati L; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, United States.
  • Moffat JG; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, United States.
  • Pang J; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, United States.
  • Sneeringer CJ; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, United States.
  • Dompe N; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, United States.
  • Cyr P; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, United States.
  • Purkey H; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, United States.
  • Boenig GL; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, United States.
  • Li J; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, United States.
  • Kolesnikov A; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, United States.
  • Larouche-Gauthier R; Paraza Pharma, Inc., 2525 Ave. Marie-Curie, Montreal, QC H4S 2E1, Canada.
  • Lai KW; WuXi AppTec Co., Ltd., 288 Fute Zhong Road, Waigaoqiao Free Trade Zone, Shanghai 200131, People's Republic of China.
  • Shen X; WuXi AppTec Co., Ltd., 288 Fute Zhong Road, Waigaoqiao Free Trade Zone, Shanghai 200131, People's Republic of China.
  • Aubert-Nicol S; Paraza Pharma, Inc., 2525 Ave. Marie-Curie, Montreal, QC H4S 2E1, Canada.
  • Chen YC; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, United States.
  • Cheong J; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, United States.
  • Crawford JJ; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, United States.
  • Hafner M; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, United States.
  • Haghshenas P; Paraza Pharma, Inc., 2525 Ave. Marie-Curie, Montreal, QC H4S 2E1, Canada.
  • Jakalian A; Paraza Pharma, Inc., 2525 Ave. Marie-Curie, Montreal, QC H4S 2E1, Canada.
  • Leclerc JP; Paraza Pharma, Inc., 2525 Ave. Marie-Curie, Montreal, QC H4S 2E1, Canada.
  • Lim NK; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, United States.
  • O'Brien T; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, United States.
  • Plise EG; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, United States.
  • Shalan H; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, United States.
  • Sturino C; Paraza Pharma, Inc., 2525 Ave. Marie-Curie, Montreal, QC H4S 2E1, Canada.
  • Wai J; WuXi AppTec Co., Ltd., 288 Fute Zhong Road, Waigaoqiao Free Trade Zone, Shanghai 200131, People's Republic of China.
  • Xiao Y; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, United States.
  • Yin J; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, United States.
  • Zhao L; Paraza Pharma, Inc., 2525 Ave. Marie-Curie, Montreal, QC H4S 2E1, Canada.
  • Gould S; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, United States.
  • Olivero A; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, United States.
  • Heffron TP; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, United States. Electronic address: heffron.timothy@gene.com.
Bioorg Med Chem Lett ; 29(16): 2294-2301, 2019 08 15.
Article en En | MEDLINE | ID: mdl-31307887
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Encefálicas / Diseño de Fármacos / Glioblastoma / Inhibidores de Proteínas Quinasas / Quinasa 4 Dependiente de la Ciclina / Quinasa 6 Dependiente de la Ciclina / Antineoplásicos Límite: Humans Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2019 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Encefálicas / Diseño de Fármacos / Glioblastoma / Inhibidores de Proteínas Quinasas / Quinasa 4 Dependiente de la Ciclina / Quinasa 6 Dependiente de la Ciclina / Antineoplásicos Límite: Humans Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2019 Tipo del documento: Article Pais de publicación: Reino Unido