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p-Terphenyls and actinomycins from a Streptomyces sp. associated with the larva of mud dauber wasp.
Lu, Dan-Dan; Ren, Jin-Wei; Du, Qian-Qian; Song, Ya-Jie; Lin, Shi-Qi; Li, Xia; Li, Er-Wei; Xie, Wei-Dong.
Afiliación
  • Lu DD; College of Marine Science, Shandong University at Weihai, Weihai, People's Republic of China.
  • Ren JW; State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, People's Republic of China.
  • Du QQ; State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, People's Republic of China.
  • Song YJ; College of Marine Science, Shandong University at Weihai, Weihai, People's Republic of China.
  • Lin SQ; State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, People's Republic of China.
  • Li X; College of Marine Science, Shandong University at Weihai, Weihai, People's Republic of China.
  • Li EW; College of Marine Science, Shandong University at Weihai, Weihai, People's Republic of China.
  • Xie WD; College of Marine Science, Shandong University at Weihai, Weihai, People's Republic of China.
Nat Prod Res ; 35(11): 1869-1873, 2021 Jun.
Article en En | MEDLINE | ID: mdl-31305144
In the course of searching for cytotoxic metabolites from insects associated actinomyces, two new natural p-terphenyl glycosides, strepantibin D (1) and strepantibin E (2), along with terferol (3), actinomycin D (4), actinomycin V (5) and actinomycin V0ß (6), were identified from the fermentation medium of a Streptomyces sp. which was obtained from the larva body of mud dauber wasp. Strepantibin D (1), previously reported as a synthetic derivative of terfestatin A, is firstly isolated as a natural p-terphenyl in this research. Strepantibin D (1) and terferol (3) showed medium cytotoxic activity against breast cancer cells MCF-7, MDA-MB-231 and BT-474. Actinomycins (4-6), especially actinomycin V (5), displayed remarkable cytotoxicity against breast cancer cells, with IC50 values ranging from 0.83 nM to 369.90 nM.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Streptomyces / Compuestos de Terfenilo / Avispas / Dactinomicina Tipo de estudio: Risk_factors_studies Límite: Animals / Humans Idioma: En Revista: Nat Prod Res Año: 2021 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Streptomyces / Compuestos de Terfenilo / Avispas / Dactinomicina Tipo de estudio: Risk_factors_studies Límite: Animals / Humans Idioma: En Revista: Nat Prod Res Año: 2021 Tipo del documento: Article Pais de publicación: Reino Unido