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Ligand-assisted synthesis and cytotoxicity of ZnSe quantum dots stabilized by N-(2-carboxyethyl)chitosans.
Bratskaya, Svetlana; Sergeeva, Kseniya; Konovalova, Mariya; Modin, Evgeny; Svirshchevskaya, Elena; Sergeev, Alexander; Mironenko, Aleksandr; Pestov, Alexandr.
Afiliación
  • Bratskaya S; Institute of Chemistry, Far Eastern Branch of RAS, 159, prosp.100-letiya Vladivostoka, Vladivostok, 690022, Russia. Electronic address: sbratska@ich.dvo.ru.
  • Sergeeva K; Institute of Automation and Control Processes, Far Eastern Branch of RAS, 5, Radio Str., Vladivostok, 690041, Russia.
  • Konovalova M; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, RAS, 16/10, Miklukho-Maklaya Str., Moscow, 117997, Russia.
  • Modin E; CIC nanoGUNE, Donostia - San Sebastian, 20018, Spain.
  • Svirshchevskaya E; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, RAS, 16/10, Miklukho-Maklaya Str., Moscow, 117997, Russia.
  • Sergeev A; Institute of Automation and Control Processes, Far Eastern Branch of RAS, 5, Radio Str., Vladivostok, 690041, Russia.
  • Mironenko A; Institute of Chemistry, Far Eastern Branch of RAS, 159, prosp.100-letiya Vladivostoka, Vladivostok, 690022, Russia.
  • Pestov A; I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of RAS, 20, S. Kovalevskoy Str., Yekaterinburg, 620990, Russia.
Colloids Surf B Biointerfaces ; 182: 110342, 2019 Oct 01.
Article en En | MEDLINE | ID: mdl-31299538
Here we report a green synthesis of ZnSe quantum dots (QDs) in aqueous solution of polyampholyte chitosan derivative - N-(2-carboxyethyl)chitosan (CEC) with substitution degrees (DS) from 0.7 to 1.3 and molecular weight (MW) of 40 kDa and 150 kDa. We have shown that the maximum intensity of photoluminescence (PL) is exhibited by ZnSe QDs synthesized in solutions of CEC with DS 1 at Se:Zn molar ratio 1:2.5. The defect-related band was predominant in the PL spectra of ZnSe QDs obtained at room temperature; however, hydrothermal treatment at 80-150 °C during 1-2 h significantly increased contribution of exciton emission to the spectra. Cytotoxicity of ZnSe QDs was investigated by MTT assay using cancer cell lines SKOV-3; SkBr-3; PANC-1; Colon-26 and human embryonic kidney cell line HEK293. Cytotoxicity of ZnSe QDs did not depend on MW or DS of CEC but significantly depended on the cell line, being the lowest for normal human cells HEK293 and breast cancer cell line SKOV-3. The hydrothermally treated ZnSe QDs showed higher toxicity toward both normal and cancer cell lines. Since ZnSe QDs were toxic for most of the investigated cancer cell lines, they cannot be used as inert tracers for bioimaging, but can be promising for further investigation for anticancer therapy.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Compuestos de Zinc / Compuestos de Selenio / Puntos Cuánticos / Quitosano Límite: Humans Idioma: En Revista: Colloids Surf B Biointerfaces Asunto de la revista: QUIMICA Año: 2019 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Compuestos de Zinc / Compuestos de Selenio / Puntos Cuánticos / Quitosano Límite: Humans Idioma: En Revista: Colloids Surf B Biointerfaces Asunto de la revista: QUIMICA Año: 2019 Tipo del documento: Article Pais de publicación: Países Bajos