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Seneca Valley virus 2C and 3C inhibit type I interferon production by inducing the degradation of RIG-I.
Wen, Wei; Yin, Mengge; Zhang, Huawei; Liu, Tingting; Chen, Huanchun; Qian, Ping; Hu, Junjie; Li, Xiangmin.
Afiliación
  • Wen W; State Key Laboratory of Agriculture Microbiology, Huazhong Agricultural University, Wuhan, 430070, PR China; Division of Animal Infectious Diseases, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, China.
  • Yin M; State Key Laboratory of Agriculture Microbiology, Huazhong Agricultural University, Wuhan, 430070, PR China; Division of Animal Infectious Diseases, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, China.
  • Zhang H; State Key Laboratory of Agriculture Microbiology, Huazhong Agricultural University, Wuhan, 430070, PR China; Division of Animal Infectious Diseases, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, China.
  • Liu T; State Key Laboratory of Agriculture Microbiology, Huazhong Agricultural University, Wuhan, 430070, PR China; Division of Animal Infectious Diseases, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, China.
  • Chen H; State Key Laboratory of Agriculture Microbiology, Huazhong Agricultural University, Wuhan, 430070, PR China; Division of Animal Infectious Diseases, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, China.
  • Qian P; State Key Laboratory of Agriculture Microbiology, Huazhong Agricultural University, Wuhan, 430070, PR China; Division of Animal Infectious Diseases, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, China.
  • Hu J; Hubei Colorectal Cancer Clinical Research Center, Hubei Cancer Hospital, Wuhan, 430071, China.
  • Li X; State Key Laboratory of Agriculture Microbiology, Huazhong Agricultural University, Wuhan, 430070, PR China; Division of Animal Infectious Diseases, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, China. Electronic address: lixiangmin@mail.hzau.edu.cn.
Virology ; 535: 122-129, 2019 09.
Article en En | MEDLINE | ID: mdl-31299488
Seneca Valley virus (SVV) is a member of the Picornaviridae family, which has been used to treat neuroendocrine cancer. The innate immune system plays an important role in SVV infection. However, few studies have elucidated the relationship between SVV infection and the host's antiviral response. In this study, SVV replication could induce the degradation of RIG-I in HEK-293T, SW620 and SK6 cells. And overexpressing retinoic acid-inducible gene I (RIG-I) could significantly inhibit SVV propagation. The viral protein 2C and 3C were essential for the degradation of RIG-I. Furthermore, 2C and 3C significantly reduced Sev or RIG-I-induced IFN-ß production. Mechanistically, 2C and 3C induced RIG-I degradation through the caspase signaling pathway. Taken together, we demonstrate the antiviral role of RIG-I against SVV and the mechanism by which SVV 2C and 3C weaken the host innate immune system.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Picornaviridae / Proteínas Virales / Interferón Tipo I / Evasión Inmune / Proteolisis / Proteína 58 DEAD Box / Interacciones Microbiota-Huesped Límite: Humans Idioma: En Revista: Virology Año: 2019 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Picornaviridae / Proteínas Virales / Interferón Tipo I / Evasión Inmune / Proteolisis / Proteína 58 DEAD Box / Interacciones Microbiota-Huesped Límite: Humans Idioma: En Revista: Virology Año: 2019 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos