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Has the sun set for seasonal affective disorder and HPA axis studies? A systematic review and future prospects.
Agustini, Bruno; Bocharova, Mariia; Walker, Adam J; Berk, Michael; Young, Allan H; Juruena, Mario F.
Afiliación
  • Agustini B; Deakin University, School of Medicine, IMPACT Strategic Research Centre, Barwon Health, Geelong, VIC, Australia. Electronic address: bagustini@deakin.edu.au.
  • Bocharova M; Centre for Affective Disorders, Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, Biomedical Research Centre (BRC), South London and Maudsley NHS Foundation Trust (SLaM) and King's College London, London, United Kingdom.
  • Walker AJ; Deakin University, School of Medicine, IMPACT Strategic Research Centre, Barwon Health, Geelong, VIC, Australia.
  • Berk M; Deakin University, School of Medicine, IMPACT Strategic Research Centre, Barwon Health, Geelong, VIC, Australia.
  • Young AH; Centre for Affective Disorders, Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, Biomedical Research Centre (BRC), South London and Maudsley NHS Foundation Trust (SLaM) and King's College London, London, United Kingdom.
  • Juruena MF; Centre for Affective Disorders, Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, Biomedical Research Centre (BRC), South London and Maudsley NHS Foundation Trust (SLaM) and King's College London, London, United Kingdom.
J Affect Disord ; 256: 584-593, 2019 09 01.
Article en En | MEDLINE | ID: mdl-31299439
OBJECTIVE: Seasonal Affective Disorder (SAD) is a form of cyclic mood disorder that tends to manifest as winter depression. SAD has anecdotally been described as a hypocortisolemic condition. However, there are no systematic reviews on SAD and Hypothalamic-Pituitary-Adrenal (HPA) axis function. This review intends to summarize these findings. METHODS: Using the PRISMA (2009) guideline recommendations we searched for relevant articles indexed in databases including MEDLINE, EMBASE, PsycINFO, and PsychArticles. The following keywords were used: "Seasonal affective disorder", OR "Winter Depression", OR "Seasonal depression" associated with: "HPA Axis" OR "cortisol" OR "CRH" OR "ACTH". RESULTS: Thirteen papers were included for qualitative analysis. Studies used both heterogeneous methods and populations. The best evidence comes from a recent study showing that SAD patients tend to demonstrate an attenuated Cortisol Awakening Response (CAR) in winter, but not in summer, compared to controls. Dexamethasone Suppression Test (DST) studies suggest SAD patients have normal suppression of the HPA axis. CONCLUSION: There is still insufficient evidence to classify SAD as a hypocortisolemic condition when compared to controls. Heterogeneous methods and samples did not allow replication of results. We discuss the limitations of these studies and provide new methods and targets to probe HPA axis function in this population. SAD can provide a unique window of opportunity to study HPA axis in affective disorders, since it is highly predictable and can be followed before, during and after episodes subsides.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sistema Hipófiso-Suprarrenal / Trastorno Afectivo Estacional / Sistema Hipotálamo-Hipofisario Tipo de estudio: Prognostic_studies / Qualitative_research / Systematic_reviews Límite: Adult / Female / Humans / Male Idioma: En Revista: J Affect Disord Año: 2019 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sistema Hipófiso-Suprarrenal / Trastorno Afectivo Estacional / Sistema Hipotálamo-Hipofisario Tipo de estudio: Prognostic_studies / Qualitative_research / Systematic_reviews Límite: Adult / Female / Humans / Male Idioma: En Revista: J Affect Disord Año: 2019 Tipo del documento: Article Pais de publicación: Países Bajos