Esterified Derivatives of Panaxadiol and Their Inhibitory Effect on HL-60, THP-1, and PC-3 Cell Lines.

Wang, Ziyi; Ding, Meng; Lin, Zhe; He, Cuiwei; Zhao, Yuqing

Wang, Ziyi; Ding, Meng; Lin, Zhe; He, Cuiwei; Zhao, Yuqing.

Afiliación

Wang Z; School of Pharmacy, Guangxi University of Traditional Chinese Medicine, Nanning, 530020, P. R. China.
Ding M; School of Functional Food and Wine, Shenyang Pharmaceutical University, Shenyang, 110016, P. R. China.
Lin Z; School of Functional Food and Wine, Shenyang Pharmaceutical University, Shenyang, 110016, P. R. China.
He C; School of Functional Food and Wine, Shenyang Pharmaceutical University, Shenyang, 110016, P. R. China.
Zhao Y; School of Pharmacy, Guangxi University of Traditional Chinese Medicine, Nanning, 530020, P. R. China.

Chem Biodivers ; 16(8): e1900188, 2019 Aug.

Article en En | MEDLINE | ID: mdl-31298488

RESUMEN

Panaxadiol is a dammarane-type ginsenoside having high ginseng content. The 3-hydroxy group of panaxadiol (PD) was modified by fatty acids and diacids. The modified panax glycol had enhanced anticancer activity. Twelve PD derivatives were evaluated and purified by chemical synthesis, column chromatography, co-synthesis, and identification. The human leukemia cells THP-1, HL-60, and human prostate cancer cell lines PC-3 were evaluated; PD derivatives were tested and evaluated inâvitro by MTT assay. The results showed that the antitumor activities of some derivatives on three tumor cell lines were better than those of PD.

Asunto(s)

Antineoplásicos Fitogénicos/farmacología; Proliferación Celular/efectos de los fármacos; Ginsenósidos/química; Panax/química; Antineoplásicos Fitogénicos/síntesis química; Antineoplásicos Fitogénicos/química; Línea Celular Tumoral; Ginsenósidos/síntesis química; Ginsenósidos/farmacología; Células HL-60; Humanos; Células PC-3; Panax/metabolismo

Palabras clave

antitumor activity; cytotoxicity; ester derivatives; panaxadiol; structural modification

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ginsenósidos / Proliferación Celular / Panax / Antineoplásicos Fitogénicos Límite: Humans Idioma: En Revista: Chem Biodivers Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2019 Tipo del documento: Article Pais de publicación: Suiza

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