Human cytochrome P450 11B2 produces aldosterone by a processive mechanism due to the lactol form of the intermediate 18-hydroxycorticosterone.

Reddish, Michael J; Guengerich, F Peter

Reddish, Michael J; Guengerich, F Peter.

Afiliación

Reddish MJ; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146.
Guengerich FP; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146. Electronic address: f.guengerich@vanderbilt.edu.

J Biol Chem ; 294(35): 12975-12991, 2019 08 30.

Article en En | MEDLINE | ID: mdl-31296661

Asunto(s)

18-Hidroxicorticosterona/metabolismo; Aldosterona/biosíntesis; Citocromo P-450 CYP11B2/metabolismo; 18-Hidroxicorticosterona/química; Aldosterona/química; Biocatálisis; Humanos; Cinética; Modelos Moleculares; Conformación Molecular

Palabras clave

CYP11B2; P450 11B2; aldosterone synthesis; conformational change; corticosterone; cytochrome P450; deoxycorticosterone; enzyme kinetics; kinetics; pre-steadystate kinetics; steroid; steroidogenesis

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Citocromo P-450 CYP11B2 / Aldosterona / 18-Hidroxicorticosterona Límite: Humans Idioma: En Revista: J Biol Chem Año: 2019 Tipo del documento: Article Pais de publicación: Estados Unidos

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