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Neuronal integration in the adult mouse olfactory bulb is a non-selective addition process.
Platel, Jean-Claude; Angelova, Alexandra; Bugeon, Stephane; Wallace, Jenelle; Ganay, Thibault; Chudotvorova, Ilona; Deloulme, Jean-Christophe; Béclin, Christophe; Tiveron, Marie-Catherine; Coré, Nathalie; Murthy, Venkatesh N; Cremer, Harold.
Afiliación
  • Platel JC; Aix-Marseille University, CNRS, IBDM, UMR 7288, Marseille, France.
  • Angelova A; Aix-Marseille University, CNRS, IBDM, UMR 7288, Marseille, France.
  • Bugeon S; Aix-Marseille University, CNRS, IBDM, UMR 7288, Marseille, France.
  • Wallace J; Department of Molecular & Cellular Biology, Harvard University, Cambridge, United States.
  • Ganay T; Aix-Marseille University, CNRS, IBDM, UMR 7288, Marseille, France.
  • Chudotvorova I; Aix-Marseille University, CNRS, IBDM, UMR 7288, Marseille, France.
  • Deloulme JC; Grenoble Institut des Neurosciences, Université Grenoble Alpes, Grenoble, France.
  • Béclin C; Aix-Marseille University, CNRS, IBDM, UMR 7288, Marseille, France.
  • Tiveron MC; Aix-Marseille University, CNRS, IBDM, UMR 7288, Marseille, France.
  • Coré N; Aix-Marseille University, CNRS, IBDM, UMR 7288, Marseille, France.
  • Murthy VN; Department of Molecular & Cellular Biology, Harvard University, Cambridge, United States.
  • Cremer H; Aix-Marseille University, CNRS, IBDM, UMR 7288, Marseille, France.
Elife ; 82019 07 11.
Article en En | MEDLINE | ID: mdl-31294694
Adult neurogenesis in the olfactory bulb (OB) is considered as a competition in which neurons scramble during a critical selection period for integration and survival. Moreover, newborn neurons are thought to replace pre-existing ones that die. Despite indirect evidence supporting this model, systematic in vivo observations are still scarce. We used two-photon in vivo imaging to study neuronal integration and survival. We show that loss of new neurons in the OB after arrival at terminal positions occurs only at low levels. Moreover, long-term observations showed that no substantial cell death occurred at later stages. Neuronal death was induced by standard doses of thymidine analogs, but disappeared when low doses were used. Finally, we demonstrate that the OB grows throughout life. This shows that neuronal selection during OB-neurogenesis does not occur after neurons reached stable positions. Moreover, this suggests that OB neurogenesis does not represent neuronal turnover but lifelong neuronal addition.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Bulbo Olfatorio / Neurogénesis / Neuronas Límite: Animals Idioma: En Revista: Elife Año: 2019 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Bulbo Olfatorio / Neurogénesis / Neuronas Límite: Animals Idioma: En Revista: Elife Año: 2019 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Reino Unido