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Biphasic effects of 5-HT1A agonism on impulsive responding are dissociable from effects on anxiety in the variable consecutive number task.
Groft, Miranda L; Normann, Marigny C; Nicklas, Paige R; Jagielo-Miller, Julia E; McLaughlin, Peter J.
Afiliación
  • Groft ML; Department of Psychology, Edinboro University of Pennsylvania, Edinboro, PA, 16444, USA.
  • Normann MC; Department of Psychology, Edinboro University of Pennsylvania, Edinboro, PA, 16444, USA.
  • Nicklas PR; Department of Psychology, Northern Illinois University, DeKalb, IL, USA.
  • Jagielo-Miller JE; Department of Psychology, Edinboro University of Pennsylvania, Edinboro, PA, 16444, USA.
  • McLaughlin PJ; Department of Psychology, Edinboro University of Pennsylvania, Edinboro, PA, 16444, USA.
Naunyn Schmiedebergs Arch Pharmacol ; 392(11): 1455-1464, 2019 11.
Article en En | MEDLINE | ID: mdl-31289857
The serotonergic 5-HT1A receptor is known to be involved in both impulsivity and anxiety-related behavior. Although anxiety and impulsivity are different constructs, it has been shown that anxiogenesis can result in impulsiveness. It is therefore important to determine if the 5-HT1A receptor is involved in the commission of impulsive actions independent of its effects on anxiety. The 5-HT1A agonist 8-OH-DPAT (0.0125-0.1 mg/kg subcutaneous) increased impulsive action at low doses, but decreased it at higher doses, on the novel paced variable consecutive number with discriminative stimulus task (VCN). Neither the 5-HT1A antagonist WAY 100,635 (0.2-1.2 mg/kg subcutaneous), nor the noradrenergic antagonist and pharmacological stressor yohimbine (1-2 mg/kg intraperitoneal) altered measures of impulsivity. Stress induced by yohimbine was sufficient to produce anxiety-like behavior in the elevated zero maze, confirming that the VCN task is a selective assay of impulsive action that is not affected by anxiety. We hypothesize that the biphasic effect of 8-OH-DPAT is due to actions on presynaptic raphe 5-HT1A autoreceptors, and also postsynaptic 5-HT1A receptors. These results suggest that this receptor mediates impulsive action and that this is not secondary to its role in anxiety.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ansiedad / Conducta Animal / 8-Hidroxi-2-(di-n-propilamino)tetralin / Receptor de Serotonina 5-HT1A / Agonistas del Receptor de Serotonina 5-HT1 / Conducta Impulsiva Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Naunyn Schmiedebergs Arch Pharmacol Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Alemania
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ansiedad / Conducta Animal / 8-Hidroxi-2-(di-n-propilamino)tetralin / Receptor de Serotonina 5-HT1A / Agonistas del Receptor de Serotonina 5-HT1 / Conducta Impulsiva Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Naunyn Schmiedebergs Arch Pharmacol Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Alemania