M-TAP Dance: Targeting PRMT1 and PRMT5 Family Members to Push Cancer Cells Over the Edge.

Srour, Nivine; Mersaoui, Sofiane Y; Richard, Stéphane

Srour, Nivine; Mersaoui, Sofiane Y; Richard, Stéphane.

Afiliación

Srour N; Segal Cancer Center, Lady Davis Institute for Medical Research and Departments of Oncology and Medicine, McGill University, Montréal, QC H3T 1E2, Canada.
Mersaoui SY; Segal Cancer Center, Lady Davis Institute for Medical Research and Departments of Oncology and Medicine, McGill University, Montréal, QC H3T 1E2, Canada.
Richard S; Segal Cancer Center, Lady Davis Institute for Medical Research and Departments of Oncology and Medicine, McGill University, Montréal, QC H3T 1E2, Canada. Electronic address: stephane.richard@mcgill.ca.

Cancer Cell ; 36(1): 3-5, 2019 07 08.

Article en En | MEDLINE | ID: mdl-31287990

RESUMEN

In this issue of Cancer Cell, Fedoriw and colleagues characterize a potent reversible inhibitor of type I PRMTs, GSK3368715, with anti-proliferative effects on numerous cancer types. Using a combination of GSK3368715 with PRMT5 inhibitors, the authors show that a threshold of overall arginine methylation reduction needs to be achieved for synergistic anti-tumor activity.

Asunto(s)

Baile; Neoplasias; Inhibidores Enzimáticos; Humanos; Metilación; Proteína-Arginina N-Metiltransferasas; Proteínas Represoras

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Baile / Neoplasias Límite: Humans Idioma: En Revista: Cancer Cell Asunto de la revista: NEOPLASIAS Año: 2019 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Estados Unidos

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