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Evaluation of genetic risk related to catechol-O-methyltransferase (COMT) and ß2-adrenergic receptor (ADRB2) activity in different diagnostic subgroups of temporomandibular disorder in Brazilian patients.
de Souza Tesch, R; Ladeira Bonato, L; Quinelato, V; Ladeira Casado, P; Rezende Vieira, A; Granjeiro, J M; Góes, C.
Afiliación
  • de Souza Tesch R; School of Medicine of Petropolis, Petropolis, Rio de Janeiro, Brazil. Electronic address: ricardotesch@fmpfase.edu.br.
  • Ladeira Bonato L; Fluminense Federal University, Niteroi, Rio de Janeiro, Brazil.
  • Quinelato V; Fluminense Federal University, Niteroi, Rio de Janeiro, Brazil.
  • Ladeira Casado P; Fluminense Federal University, Niteroi, Rio de Janeiro, Brazil.
  • Rezende Vieira A; School of Dental Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
  • Granjeiro JM; National Institute of Metrology, Quality and Technology, Rio de Janeiro, Brazil.
  • Góes C; Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Int J Oral Maxillofac Surg ; 49(2): 237-243, 2020 Feb.
Article en En | MEDLINE | ID: mdl-31285095
The aim of this study was to evaluate the possible association between polymorphisms in the catechol-O-methyltransferase (COMT) and ß2-adrenergic receptor (ADRB2) genes and muscular temporomandibular disorders (TMD). This was a case-control study. Individuals were evaluated using the Research Diagnostic Criteria for Temporomandibular Disorders and were divided into three groups: unaffected (no TMD) (n=154); exclusively muscular TMD (n=49); exclusively articular TMD (n=49). Genomic DNA was obtained from saliva samples, and single nucleotide polymorphisms in the COMT (rs165774, rs6269, rs9332377) and ADRB2 (rs2053044, rs1042713, rs1042714) genes were investigated. The TT genotype for the COMT rs9332377 gene was highly associated with the presence of muscular TMD (P= 0.03). With respect to the ADRB2 gene, the non-polymorphic AA genotype in the rs1042713 region was more prevalent in the articular TMD group than in the muscular TMD group (P= 0.05). This study supports the hypothesis that alterations in the COMT and ADRB2 genes influence the muscular pathophysiology.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastornos de la Articulación Temporomandibular / Catecol O-Metiltransferasa Tipo de estudio: Diagnostic_studies / Etiology_studies / Observational_studies / Risk_factors_studies Límite: Humans País/Región como asunto: America do sul / Brasil Idioma: En Revista: Int J Oral Maxillofac Surg Asunto de la revista: ODONTOLOGIA Año: 2020 Tipo del documento: Article Pais de publicación: Dinamarca
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastornos de la Articulación Temporomandibular / Catecol O-Metiltransferasa Tipo de estudio: Diagnostic_studies / Etiology_studies / Observational_studies / Risk_factors_studies Límite: Humans País/Región como asunto: America do sul / Brasil Idioma: En Revista: Int J Oral Maxillofac Surg Asunto de la revista: ODONTOLOGIA Año: 2020 Tipo del documento: Article Pais de publicación: Dinamarca