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Stable Deuterium Labeling of Histidine-Rich Lysine-Based Dendrimers.
Sheveleva, Nadezhda N; Markelov, Denis A; Vovk, Mikhail A; Tarasenko, Irina I; Mikhailova, Mariya E; Ilyash, Maxim Yu; Neelov, Igor M; Lahderanta, Erkki.
Afiliación
  • Sheveleva NN; Saint Petersburg State University, 7/9 Universitetskaya nab, 199034 Saint Petersburg, Russia.
  • Markelov DA; Saint Petersburg State University, 7/9 Universitetskaya nab, 199034 Saint Petersburg, Russia. dmarkelov@spbu.ru.
  • Vovk MA; Saint Petersburg State University, 7/9 Universitetskaya nab, 199034 Saint Petersburg, Russia.
  • Tarasenko II; Institute of Macromolecular Compounds, Russian Academy of Sciences, Bolshoi Prospect 31, V.O., 199004 Saint Petersburg, Russia.
  • Mikhailova ME; Saint Petersburg State University, 7/9 Universitetskaya nab, 199034 Saint Petersburg, Russia.
  • Ilyash MY; Saint Petersburg National Research University of Information Technologies, Mechanics and Optics (ITMO University), Kronverkskiy pr. 49, 197101 Saint Petersburg, Russia.
  • Neelov IM; Saint Petersburg National Research University of Information Technologies, Mechanics and Optics (ITMO University), Kronverkskiy pr. 49, 197101 Saint Petersburg, Russia.
  • Lahderanta E; Department of Physics, LUT University, Box 20, 53851 Lappeenranta, Finland.
Molecules ; 24(13)2019 Jul 06.
Article en En | MEDLINE | ID: mdl-31284551
Peptide dendrimers, due to their biocompatibility and low toxicity, are highly promising candidates as nanocarriers for drugs and genes. The development of this kind of delivery system requires reliable monitoring of their metabolic and biological pathways. In this respect, hydrogen isotope labeling has tremendous importance, being a safe tool for detection of the labeled nanocarriers. In this work, we have synthesized new histidine-rich lysine-based dendrimers (Lys-2His dendrimer) with two linear histidine (His) residues in every inner segment. The presence of His residues has enabled us to perform controlled deuteration of Lys-2His dendrimers. The high deuteration degree (around 70%) does not practically change after redissolving the samples in H2O and heating them at 40 °C, which indicates the isotopic label stability.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Deuterio / Dendrímeros / Histidina / Marcaje Isotópico / Lisina Idioma: En Revista: Molecules Asunto de la revista: BIOLOGIA Año: 2019 Tipo del documento: Article País de afiliación: Rusia Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Deuterio / Dendrímeros / Histidina / Marcaje Isotópico / Lisina Idioma: En Revista: Molecules Asunto de la revista: BIOLOGIA Año: 2019 Tipo del documento: Article País de afiliación: Rusia Pais de publicación: Suiza