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Automated production of a sphingosine-1 phosphate receptor 1 (S1P1) PET radiopharmaceutical [11C]CS1P1 for human use.
Luo, Zonghua; Gu, Jiwei; Dennett, Robert C; Gaehle, Gregory G; Perlmutter, Joel S; Chen, Delphine L; Benzinger, Tammie L S; Tu, Zhude.
Afiliación
  • Luo Z; Department of Radiology, Washington University School of Medicine, St. Louis, MO, 63110, USA.
  • Gu J; Department of Radiology, Washington University School of Medicine, St. Louis, MO, 63110, USA.
  • Dennett RC; Department of Radiology, Washington University School of Medicine, St. Louis, MO, 63110, USA.
  • Gaehle GG; Department of Radiology, Washington University School of Medicine, St. Louis, MO, 63110, USA.
  • Perlmutter JS; Department of Radiology, Washington University School of Medicine, St. Louis, MO, 63110, USA; Department of Neurology, Neuroscience, Physical Therapy and Occupational Therapy, Washington University School of Medicine, St. Louis, MO, 63110, USA.
  • Chen DL; Department of Radiology, Washington University School of Medicine, St. Louis, MO, 63110, USA.
  • Benzinger TLS; Department of Radiology, Washington University School of Medicine, St. Louis, MO, 63110, USA.
  • Tu Z; Department of Radiology, Washington University School of Medicine, St. Louis, MO, 63110, USA. Electronic address: tuz@mir.wustl.edu.
Appl Radiat Isot ; 152: 30-36, 2019 Oct.
Article en En | MEDLINE | ID: mdl-31280104
Automated synthesis of a radiopharmaceutical 3-((2-fluoro-4-(5-(2'-methyl-2-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)-1,2,4-oxadiazol-3-yl)benzyl) (methyl-11C)amino)propanoic acid ([11C]CS1P1) for PET imaging sphingosine-1 phosphate receptor 1 (S1P1) was accomplished by a two-step-one-pot procedure in a Siemens CTI methylation automated module using TR-19 cyclotron. The synthesis of [11C]CS1P1 was successfully validated under current Good Manufacturing Practices (cGMP) conditions, resulting in a consistent average radiochemical yield of ∼15%, molar activity of ∼3129 GBq/µmol (decay corrected to end of bombardment, EOB), and radiochemical purity > 95%. The radiopharmaceutical product meets all quality control criteria for human use for an Investigational New Drug (IND) application to permit human studies.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Radioisótopos de Carbono / Radiofármacos / Tomografía de Emisión de Positrones / Receptores de Esfingosina-1-Fosfato Límite: Humans Idioma: En Revista: Appl Radiat Isot Asunto de la revista: MEDICINA NUCLEAR / SAUDE AMBIENTAL Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Radioisótopos de Carbono / Radiofármacos / Tomografía de Emisión de Positrones / Receptores de Esfingosina-1-Fosfato Límite: Humans Idioma: En Revista: Appl Radiat Isot Asunto de la revista: MEDICINA NUCLEAR / SAUDE AMBIENTAL Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido