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Depression and ADHD-Related Risk for Substance Use in Adolescence and Early Adulthood: Concurrent and Prospective Associations in the MTA.
Howard, Andrea L; Kennedy, Traci M; Macdonald, Erin P; Mitchell, John T; Sibley, Margaret H; Roy, Arunima; Arnold, L Eugene; Epstein, Jeffery N; Hinshaw, Stephen P; Hoza, Betsy; Stehli, Annamarie; Swanson, James M; Molina, Brooke S G.
Afiliación
  • Howard AL; Department of Psychology, Carleton University, Ottawa, ON, K1S 5B6, Canada. andrea.howard@carleton.ca.
  • Kennedy TM; Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
  • Macdonald EP; Department of Psychology, Carleton University, Ottawa, ON, K1S 5B6, Canada.
  • Mitchell JT; Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA.
  • Sibley MH; Department of Psychiatry, Florida International University, Miami, FL, USA.
  • Roy A; Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON, Canada.
  • Arnold LE; Department of Psychiatry and Behavioral Health, Ohio State University, Columbus, OH, USA.
  • Epstein JN; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
  • Hinshaw SP; Department of Psychology, University of California, Berkeley, Berkeley, CA, USA.
  • Hoza B; Department of Psychological Science, University of Vermont, Burlington, VT, USA.
  • Stehli A; Department of Pediatrics, University of California, Irvine, Irvine, CA, USA.
  • Swanson JM; Department of Pediatrics, University of California, Irvine, Irvine, CA, USA.
  • Molina BSG; Departments of Psychiatry, Psychology, and Pediatrics, University of Pittsburgh, Pittsburgh, PA, USA.
J Abnorm Child Psychol ; 47(12): 1903-1916, 2019 12.
Article en En | MEDLINE | ID: mdl-31273568
Childhood attention-deficit/hyperactivity disorder (ADHD) is prospectively linked to substance use and disorder. Depression emerging in adolescence is an understudied risk factor that may explain some of this risk. In the present study, we considered mediating and moderating roles of adolescent depression in explaining this association by using longitudinal data from the prospective 16-year follow-up of the Multimodal Treatment Study of ADHD (MTA). Participants were 547 children diagnosed with DSM-IV ADHD Combined Type, and 258 age- and sex-matched comparison children. In adolescence, depressive symptoms did not exacerbate effects of childhood ADHD on any substance use. For both groups, time-varying and average depressive symptoms were associated with more frequent use of all substances. Prospectively, we found no evidence of depression mediation to adult substance use. However, adolescent depression moderated the association between childhood ADHD and adult marijuana use. Although adults without ADHD histories used marijuana more frequently if they had elevated depressive symptoms in adolescence, marijuana use by adults with ADHD histories was independent of their adolescent depression. In adulthood, depression diagnoses and ADHD persistence continued to operate as independent, additive correlates of substance use risk. Our findings suggest a circumscribed role for depression in substance use risk that adds to, but does not alter or explain, ADHD-related risk.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastorno por Déficit de Atención con Hiperactividad / Trastornos Relacionados con Sustancias / Depresión Tipo de estudio: Etiology_studies / Observational_studies / Risk_factors_studies Límite: Adolescent / Adult / Child / Female / Humans / Male Idioma: En Revista: J Abnorm Child Psychol Año: 2019 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastorno por Déficit de Atención con Hiperactividad / Trastornos Relacionados con Sustancias / Depresión Tipo de estudio: Etiology_studies / Observational_studies / Risk_factors_studies Límite: Adolescent / Adult / Child / Female / Humans / Male Idioma: En Revista: J Abnorm Child Psychol Año: 2019 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Estados Unidos