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Prednisolone treatment induced temporary factor IX normalization in mild hemophilia B who required an epidural infiltration: A case report.
Carrette, M; Feugray, G; Chamouni, P; Le Cam Duchez, V; Fretigny, M; Barbay, V; Billoir, P.
Afiliación
  • Carrette M; Rouen University Hospital, Vascular Hemostasis Unit, F 76000 Rouen, France.
  • Feugray G; Rouen University Hospital, Vascular Hemostasis Unit, F 76000 Rouen, France.
  • Chamouni P; Rouen University Hospital, Hemophilia Care Center, F 76000 Rouen, France.
  • Le Cam Duchez V; Rouen University Hospital, Hemophilia Care Center, F 76000 Rouen, France; Normandie Univ, UNIROUEN, INSERM U1096, Rouen University Hospital, Vascular Hemostasis Unit, F76000 Rouen, France.
  • Fretigny M; Service d'Hématologie Biologique, Groupement Hospitalier Est, CHU de Lyon, France.
  • Barbay V; Rouen University Hospital, Vascular Hemostasis Unit, Hemophilia Care Center, F 76000 Rouen, France.
  • Billoir P; Normandie Univ, UNIROUEN, INSERM U1096, Rouen University Hospital, Vascular Hemostasis Unit, F76000 Rouen, France. Electronic address: paul.billoir@chu-rouen.fr.
Transfus Apher Sci ; 58(4): 512-514, 2019 Aug.
Article en En | MEDLINE | ID: mdl-31272859
A 31-year-old man with mild hemophilia B developed a herniated disc treated with prednisolone for back pain. Surprisingly, hemostasis result tests performed before epidural infiltration were a normal activated partial thrombin time at 36.1 s. (normal range 27.9-37.7 s.) and factor IX (FIX) level 76% (normal range>70%), 13 days after prednisolone introduction. After a second control with a normal FIX level and a second genetic confirmation of hemophilia, no FIX concentrates was administered to perform the infiltration, which occurred without hemorrhagic complication. This new case of FIX normalization showed the necessity to have a perfect knowledge of patient's treatment to avoid misdiagnosis and a temporary normal hemostasis permit to perform epidural infiltration without replacement therapy.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Factor IX / Prednisolona / Hemofilia B / Desplazamiento del Disco Intervertebral Límite: Adult / Humans / Male Idioma: En Revista: Transfus Apher Sci Asunto de la revista: HEMATOLOGIA Año: 2019 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Factor IX / Prednisolona / Hemofilia B / Desplazamiento del Disco Intervertebral Límite: Adult / Humans / Male Idioma: En Revista: Transfus Apher Sci Asunto de la revista: HEMATOLOGIA Año: 2019 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Reino Unido