Dystrophin R16/17 protein therapy restores sarcolemmal nNOS in trans and improves muscle perfusion and function.

Zhao, Junling; Yang, Hsiao Tung; Wasala, Lakmini; Zhang, Keqing; Yue, Yongping; Duan, Dongsheng; Lai, Yi

Zhao, Junling; Yang, Hsiao Tung; Wasala, Lakmini; Zhang, Keqing; Yue, Yongping; Duan, Dongsheng; Lai, Yi.

Afiliación

Zhao J; Department of Molecular Microbiology and Immunology, School of Medicine, University of Missouri, Medical Sciences Building, One Hospital Drive, Columbia, MO, 65212, USA.
Yang HT; Department of Biomedical Sciences, College of Veterinary Medicine, University of Missouri, Columbia, MO, 65212, USA.
Wasala L; Department of Molecular Microbiology and Immunology, School of Medicine, University of Missouri, Medical Sciences Building, One Hospital Drive, Columbia, MO, 65212, USA.
Zhang K; Department of Molecular Microbiology and Immunology, School of Medicine, University of Missouri, Medical Sciences Building, One Hospital Drive, Columbia, MO, 65212, USA.
Yue Y; Department of Molecular Microbiology and Immunology, School of Medicine, University of Missouri, Medical Sciences Building, One Hospital Drive, Columbia, MO, 65212, USA.
Duan D; Department of Molecular Microbiology and Immunology, School of Medicine, University of Missouri, Medical Sciences Building, One Hospital Drive, Columbia, MO, 65212, USA. duand@health.missouri.edu.
Lai Y; Department of Biomedical Sciences, College of Veterinary Medicine, University of Missouri, Columbia, MO, 65212, USA. duand@health.missouri.edu.

Mol Med ; 25(1): 31, 2019 07 02.

Article en En | MEDLINE | ID: mdl-31266455

Asunto(s)

Músculo Esquelético/metabolismo; Óxido Nítrico Sintasa de Tipo I/metabolismo; Sarcolema/metabolismo; Utrofina/metabolismo; Animales; Humanos; Ratones; Ratones Transgénicos; Distrofia Muscular de Duchenne/metabolismo; Distrofia Muscular de Duchenne/terapia; Mutación/genética; Óxido Nítrico Sintasa de Tipo I/genética; Óxido Nítrico Sintasa de Tipo I/farmacología; Unión Proteica/genética; Sarcolema/genética; Sarcolema/patología; Utrofina/genética

Palabras clave

Blood perfusion; Dystrophin R16/17; Dystrophinopathy; Functional ischemia; Protein therapy; Sarcolemmal nNOS

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sarcolema / Músculo Esquelético / Utrofina / Óxido Nítrico Sintasa de Tipo I Límite: Animals / Humans Idioma: En Revista: Mol Med Asunto de la revista: BIOLOGIA MOLECULAR Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido

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