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In vitro digestion models to evaluate lipid based drug delivery systems; present status and current trends.
Berthelsen, Ragna; Klitgaard, Mette; Rades, Thomas; Müllertz, Anette.
Afiliación
  • Berthelsen R; University of Copenhagen, Department of Pharmacy, Universitetsparken 2, 2100 Copenhagen, Denmark. Electronic address: ragna.berthelsen@sund.ku.dk.
  • Klitgaard M; University of Copenhagen, Department of Pharmacy, Universitetsparken 2, 2100 Copenhagen, Denmark. Electronic address: mette.klitgaard@sund.ku.dk.
  • Rades T; University of Copenhagen, Department of Pharmacy, Universitetsparken 2, 2100 Copenhagen, Denmark. Electronic address: thomas.Rades@sund.ku.dk.
  • Müllertz A; University of Copenhagen, Department of Pharmacy, Universitetsparken 2, 2100 Copenhagen, Denmark. Electronic address: anette.mullertz@sund.ku.dk.
Adv Drug Deliv Rev ; 142: 35-49, 2019 03 01.
Article en En | MEDLINE | ID: mdl-31265861
During the past two decades, a range of in vitro models simulating the digestion processes occurring in the stomach and small intestine have been developed to characterize lipid based drug delivery systems (LbDDSs). This review describes the presently existing range of in vitro digestion models and their use in the field of oral drug delivery. The models are evaluated in terms of their suitability to assess LbDDSs, and their ability to produce in vitro - in vivo correlations (IVIVCs). While the pH-stat lipolysis model is by far the most commonly utilized in vitro digestion model in relation to characterizing LbDDSs, a series of recent studies have shown a lack of IVIVCs limiting its future use. Presently, no single in vitro digestion model exists which is able to predict the in vivo performance of various LbDDSs. However, recent research has shown the potential of combined digestion-permeation models as well as species specific digestion models.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sistemas de Liberación de Medicamentos / Digestión / Lípidos / Modelos Biológicos Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Adv Drug Deliv Rev Asunto de la revista: FARMACOLOGIA / TERAPIA POR MEDICAMENTOS Año: 2019 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sistemas de Liberación de Medicamentos / Digestión / Lípidos / Modelos Biológicos Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Adv Drug Deliv Rev Asunto de la revista: FARMACOLOGIA / TERAPIA POR MEDICAMENTOS Año: 2019 Tipo del documento: Article Pais de publicación: Países Bajos