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Basic Concepts on the Role of Nuclear Factor Erythroid-Derived 2-Like 2 (Nrf2) in Age-Related Diseases.
Francisqueti-Ferron, Fabiane Valentini; Ferron, Artur Junio Togneri; Garcia, Jéssica Leite; Silva, Carol Cristina Vágula de Almeida; Costa, Mariane Róvero; Gregolin, Cristina Schmitt; Moreto, Fernando; Ferreira, Ana Lúcia A; Minatel, Igor Otávio; Correa, Camila Renata.
Afiliación
  • Francisqueti-Ferron FV; Medical School, São Paulo State University, Botucatu 18618-970, SP, Brazil. fabiane_vf@yahoo.com.br.
  • Ferron AJT; Medical School, São Paulo State University, Botucatu 18618-970, SP, Brazil.
  • Garcia JL; Medical School, São Paulo State University, Botucatu 18618-970, SP, Brazil.
  • Silva CCVA; Medical School, São Paulo State University, Botucatu 18618-970, SP, Brazil.
  • Costa MR; Medical School, São Paulo State University, Botucatu 18618-970, SP, Brazil.
  • Gregolin CS; Medical School, São Paulo State University, Botucatu 18618-970, SP, Brazil.
  • Moreto F; Medical School, São Paulo State University, Botucatu 18618-970, SP, Brazil.
  • Ferreira ALA; Medical School, São Paulo State University, Botucatu 18618-970, SP, Brazil.
  • Minatel IO; Institute of Biosciences, São Paulo State University, Botucatu 18618-689, SP, Brazil.
  • Correa CR; Medical School, São Paulo State University, Botucatu 18618-970, SP, Brazil.
Int J Mol Sci ; 20(13)2019 Jun 29.
Article en En | MEDLINE | ID: mdl-31261912
The transcription factor Nrf2 (nuclear factor erythroid 2-related factor 2) is one of the most important oxidative stress regulator in the human body. Once Nrf2 regulates the expression of a large number of cytoprotective genes, it plays a crucial role in the prevention of several diseases, including age-related disorders. However, the involvement of Nrf2 on these conditions is complex and needs to be clarified. Here, a brief compilation of the Nrf2 enrollment in the pathophysiology of the most common age-related diseases and bring insights for future research on the Nrf2 pathway is described. This review shows a controversial response of this transcriptional factor on the presented diseases. This reinforces the necessity of more studies to investigate modulation strategies for Nrf2, making it a possible therapeutic target in the treatment of age-related disorders.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Envejecimiento / Estrés Oxidativo / Factor 2 Relacionado con NF-E2 Límite: Animals / Humans Idioma: En Revista: Int J Mol Sci Año: 2019 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Envejecimiento / Estrés Oxidativo / Factor 2 Relacionado con NF-E2 Límite: Animals / Humans Idioma: En Revista: Int J Mol Sci Año: 2019 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Suiza