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Sotrastaurin attenuates the stemness of gastric cancer cells by targeting PKCδ.
Yuan, Yuan; Yangmei, Zhang; Rongrong, Sun; Xiaowu, Li; Youwei, Zhang; Sun, Sanyuan.
Afiliación
  • Yuan Y; Department of Medical Oncology, Xuzhou Central Hospital, Xuzhou Medical University, XuZhou, 221009, China.
  • Yangmei Z; Department of Medical Oncology, Xuzhou Central Hospital, Xuzhou Medical University, XuZhou, 221009, China.
  • Rongrong S; Department of Medical Oncology, Xuzhou Central Hospital, Xuzhou Medical University, XuZhou, 221009, China.
  • Xiaowu L; Department of Medical Oncology, Xuzhou Central Hospital, Xuzhou Medical University, XuZhou, 221009, China.
  • Youwei Z; Department of Medical Oncology, Xuzhou Central Hospital, Xuzhou Medical University, XuZhou, 221009, China. Electronic address: youwei_zhang@yeah.net.
  • Sun S; Department of Medical Oncology, Xuzhou Central Hospital, Xuzhou Medical University, XuZhou, 221009, China. Electronic address: sayuan_sun@163.com.
Biomed Pharmacother ; 117: 109165, 2019 Sep.
Article en En | MEDLINE | ID: mdl-31261030
Gastric cancer (GC) is one of the most lethal malignancies. Chemoresistance and metastasis are the main cause of treatment failure. Cancer stem cells (CSCs) have been proven to be essential for cancer metastasis and chemoresistance. PKCδ (protein kinase C-δ), a novel member of PKC family, has been validated as a synthetic lethal target in multiple cancers, and contributes to tyrosine kinase inhibitors (TKI) resistance in EGFR-mutant NSCLC (non-small cell lung cancer) patients. However, its role in GC is unclear. Here, we systematically investigate its role in GC, especially in regulating GC stem cell-like properties. We found that PKCδ positively regulated the metastasis, chemoresistance, and stem cell-like characteristics of GC cells, and its inhibitor sotrastaurin could rescue the above effects mediated by PKCδ. Importantly, sotrastaurin could also weaken metastasis, chemoresistance, and stem cell-like characteristics of adriamycin-resistant GC cells via PKCδ suppression, indicating sotrastaurin is an ideal candidate for combinational therapy to overcome chemoresistance for GC.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pirroles / Quinazolinas / Neoplasias Gástricas / Células Madre Neoplásicas / Proteína Quinasa C-delta Límite: Humans Idioma: En Revista: Biomed Pharmacother Año: 2019 Tipo del documento: Article País de afiliación: China Pais de publicación: Francia
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pirroles / Quinazolinas / Neoplasias Gástricas / Células Madre Neoplásicas / Proteína Quinasa C-delta Límite: Humans Idioma: En Revista: Biomed Pharmacother Año: 2019 Tipo del documento: Article País de afiliación: China Pais de publicación: Francia