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Co3O4 needles on Au honeycomb as a non-invasive electrochemical biosensor for glucose in saliva.
Coyle, Victoria E; Kandjani, Ahmad E; Field, Matthew R; Hartley, Patrick; Chen, Miao; Sabri, Ylias M; Bhargava, Suresh K.
Afiliación
  • Coyle VE; Centre for Advanced Materials and Industrial Chemistry (CAMIC), School of Science, RMIT University, Melbourne, Victoria, 3001, Australia; CSIRO, Bayview Avenue, Clayton, Victoria, 3168, Australia.
  • Kandjani AE; Centre for Advanced Materials and Industrial Chemistry (CAMIC), School of Science, RMIT University, Melbourne, Victoria, 3001, Australia.
  • Field MR; RMIT Microscopy & Microanalysis Facility, RMIT University, Melbourne, Australia.
  • Hartley P; CSIRO, Bayview Avenue, Clayton, Victoria, 3168, Australia.
  • Chen M; Centre for Advanced Materials and Industrial Chemistry (CAMIC), School of Science, RMIT University, Melbourne, Victoria, 3001, Australia; CSIRO, Bayview Avenue, Clayton, Victoria, 3168, Australia.
  • Sabri YM; Centre for Advanced Materials and Industrial Chemistry (CAMIC), School of Science, RMIT University, Melbourne, Victoria, 3001, Australia. Electronic address: ylias.sabri@rmit.edu.au.
  • Bhargava SK; Centre for Advanced Materials and Industrial Chemistry (CAMIC), School of Science, RMIT University, Melbourne, Victoria, 3001, Australia. Electronic address: suresh.bhargava@rmit.edu.au.
Biosens Bioelectron ; 141: 111479, 2019 Sep 15.
Article en En | MEDLINE | ID: mdl-31260903
While glucose monitoring technology is widely available, the continued prevalence of diabetes around the world coupled with its debilitating effects continues to grow. The significant limitations which exist in the current technology, instils the need for materials capable of non-invasive glucose detection. In this study a unique non-enzymatic electrochemical glucose sensor was developed, utilising a gold honeycomb-like framework upon which sharp Co3O4 needles are anchored. This composite nanomaterial demonstrates excellent sensing performance in glucose concentrations ranging between 20 µM and 4 mM, exceeding the range required for non-invasive glucose sensing. In conjunction with this high sensitivity (2.014 mA mM-1·cm-2), the material possesses excellent selectivity towards glucose for commonly interfering physiological species such as uric acid and ascorbic acid. Glucose detection in synthetic saliva was then performed showing excellent capability in the low concentration range (20 µM-1 mM) for non-invasive sensing performance. Further tests showed good selectivity of the sensor in physiological contaminants commonly found in saliva such as cortisol and dopamine. This development provides excellent scope to create next-generation non-invasive diabetes monitoring platforms, with excellent performance when detecting low glucose concentrations in complex solutions such as saliva.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Óxidos / Saliva / Técnicas Biosensibles / Cobalto / Nanoestructuras / Glucosa / Oro Tipo de estudio: Risk_factors_studies Límite: Humans Idioma: En Revista: Biosens Bioelectron Asunto de la revista: BIOTECNOLOGIA Año: 2019 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Óxidos / Saliva / Técnicas Biosensibles / Cobalto / Nanoestructuras / Glucosa / Oro Tipo de estudio: Risk_factors_studies Límite: Humans Idioma: En Revista: Biosens Bioelectron Asunto de la revista: BIOTECNOLOGIA Año: 2019 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Reino Unido