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Plasma FGF-21 and GDF-15 are elevated in different inherited metabolic diseases and are not diagnostic for mitochondrial disorders.
Tsygankova, Polina G; Itkis, Yulia S; Krylova, Tatiana D; Kurkina, Marina V; Bychkov, Igor O; Ilyushkina, Aleksandra A; Zabnenkova, Viktoria V; Mikhaylova, Svetlana V; Pechatnikova, Natalia L; Sheremet, Natalia L; Zakharova, Ekaterina Y.
Afiliación
  • Tsygankova PG; Laboratory of Inherited Metabolic Diseases, Research Centre for Medical Genetics, Moscow, Russia.
  • Itkis YS; Laboratory of DNA-Diagnostic, Research Centre for Medical Genetics, Moscow, Russia.
  • Krylova TD; Laboratory of Inherited Metabolic Diseases, Research Centre for Medical Genetics, Moscow, Russia.
  • Kurkina MV; Laboratory of DNA-Diagnostic, Research Centre for Medical Genetics, Moscow, Russia.
  • Bychkov IO; Laboratory of Inherited Metabolic Diseases, Research Centre for Medical Genetics, Moscow, Russia.
  • Ilyushkina AA; Laboratory of DNA-Diagnostic, Research Centre for Medical Genetics, Moscow, Russia.
  • Zabnenkova VV; Laboratory of Inherited Metabolic Diseases, Research Centre for Medical Genetics, Moscow, Russia.
  • Mikhaylova SV; Laboratory of DNA-Diagnostic, Research Centre for Medical Genetics, Moscow, Russia.
  • Pechatnikova NL; Laboratory of Inherited Metabolic Diseases, Research Centre for Medical Genetics, Moscow, Russia.
  • Sheremet NL; Laboratory of DNA-Diagnostic, Research Centre for Medical Genetics, Moscow, Russia.
  • Zakharova EY; Laboratory of Inherited Metabolic Diseases, Research Centre for Medical Genetics, Moscow, Russia.
J Inherit Metab Dis ; 42(5): 918-933, 2019 09.
Article en En | MEDLINE | ID: mdl-31260105
Recently, the plasma cytokines FGF-21 and GDF-15 were described as cellular metabolic regulators. They share an endocrine function and are highly expressed in the liver under stress and during starvation. Several studies found that these markers have high sensitivity and specificity for the diagnosis of mitochondrial diseases, especially those with prominent muscular involvement. In our study, we aimed to determine whether these markers could help distinguish mitochondrial diseases from other groups of inherited diseases. We measured plasma FGF-21 and GDF-15 concentrations in 122 patients with genetically confirmed primary mitochondrial disease and 127 patients with non-mitochondrial inherited diseases. Although GDF-15 showed better analytical characteristics (sensitivity = 0.66, specificity = 0.64, area under the curve [AUC] = 0.88) compared to FGF-21 (sensitivity = 0.51, specificity = 0.76, AUC = 0.78) in the pediatric group of mitochondrial diseases, both markers were also elevated in a variety of non-mitochondrial diseases, especially those with liver involvement (Gaucher disease, galactosemia, glycogenosis types 1a, 1b, 9), organic acidurias and some leukodystrophies. Thus, the overall positive and negative predictive values were not acceptable for these measurements to be used as diagnostic tests for mitochondrial diseases (FGF-21 positive predictive value [PPV] = 34%, negative predictive value [NPV] = 73%; GDF-15 PPV = 47%, NPV = 28%). We suggest that FGF-21 and GDF-15 increase in patients with metabolic diseases with metabolic or oxidative stress and inflammation.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Factor 15 de Diferenciación de Crecimiento / Factores de Crecimiento de Fibroblastos / Enfermedades Metabólicas Tipo de estudio: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adolescent / Adult / Child / Child, preschool / Female / Humans / Infant / Male / Middle aged Idioma: En Revista: J Inherit Metab Dis Año: 2019 Tipo del documento: Article País de afiliación: Rusia Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Factor 15 de Diferenciación de Crecimiento / Factores de Crecimiento de Fibroblastos / Enfermedades Metabólicas Tipo de estudio: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adolescent / Adult / Child / Child, preschool / Female / Humans / Infant / Male / Middle aged Idioma: En Revista: J Inherit Metab Dis Año: 2019 Tipo del documento: Article País de afiliación: Rusia Pais de publicación: Estados Unidos