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Catha Edulis Active Principle, Cathinone, Suppresses Motor Coordination, Accelerates Anxiety and Alters the Levels of Dopamine and its Metabolites in the Limbic Areas of Male Swiss Albino Mice.
Safhi, Mohammed M; Alam, Mohammad Firoz; Khuwaja, Gulrana; Hussain, Sohail; Siddiqui, Mohammed Hakeem; Islam, Farah; Khardali, Ibrahim; Al-Sanosi, Rashad Mohammed; Alhazmi, Hassan A; Khan, Andleeb; Islam, Fakhrul.
Afiliación
  • Safhi MM; Neuroscience and Toxicology Unit College of Pharmacy, Jazan University Ministry of Education, Jazan, Kingdom of Saudi Arabia.
  • Alam MF; Neuroscience and Toxicology Unit College of Pharmacy, Jazan University Ministry of Education, Jazan, Kingdom of Saudi Arabia.
  • Khuwaja G; Neuroscience and Toxicology Unit College of Pharmacy, Jazan University Ministry of Education, Jazan, Kingdom of Saudi Arabia.
  • Hussain S; Neuroscience and Toxicology Unit College of Pharmacy, Jazan University Ministry of Education, Jazan, Kingdom of Saudi Arabia.
  • Siddiqui MH; Neuroscience and Toxicology Unit College of Pharmacy, Jazan University Ministry of Education, Jazan, Kingdom of Saudi Arabia.
  • Islam F; Neuroscience and Toxicology Unit College of Pharmacy, Jazan University Ministry of Education, Jazan, Kingdom of Saudi Arabia.
  • Khardali I; Poison Control and Medical Forensic Chemistry Center, Ministry of Health Jazan, Jazan, Kingdom of Saudi Arabia.
  • Al-Sanosi RM; Substance Abuse Research Center, Jazan University, Ministry of Education, Jazan, Kingdom of Saudi Arabia.
  • Alhazmi HA; Substance Abuse Research Center, Jazan University, Ministry of Education, Jazan, Kingdom of Saudi Arabia.
  • Khan A; Department of Pharmaceutical Chemistry, College of Pharmacy, Jazan University, Ministry of Education, Jazan, Kingdom of Saudi Arabia.
  • Islam F; Neuroscience and Toxicology Unit College of Pharmacy, Jazan University Ministry of Education, Jazan, Kingdom of Saudi Arabia.
Acta Pharm ; 68(4): 485-495, 2018 Dec 01.
Article en En | MEDLINE | ID: mdl-31259709
Cathinone, the active principle of khat (Catha edulis), stimulates, excites and produces euphoric feelings in khat users. Locomotor and rearing activities, either individual or in groups, of male Swiss albino mice were decreased significantly compared to the control. Motor coordination tests (rotarod, rope climb and grip tests) have shown decreased motor performance in the mice treated with cathinone compared to the control. The elevated plus maze test has shown significant anxiety in the mice compared to the control. Contents of dopamine and its metabolite, homovanillic acid, were increased in the limbic areas compared to the control group. In contrast, contents of 3,4-dihydroxyphenyl acetic acid were depleted significantly and dose dependently compared to the control group in the limbic areas of mice. In conclusion, natural cathinone has depleted motor coordination, accelerated anxiety in mice and altered the contents of dopamine and its metabolites.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Dopamina / Catha / Alcaloides / Locomoción Límite: Animals Idioma: En Revista: Acta Pharm Asunto de la revista: FARMACIA / FARMACOLOGIA Año: 2018 Tipo del documento: Article Pais de publicación: Polonia
Texto completo
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Imprimir
XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Dopamina / Catha / Alcaloides / Locomoción Límite: Animals Idioma: En Revista: Acta Pharm Asunto de la revista: FARMACIA / FARMACOLOGIA Año: 2018 Tipo del documento: Article Pais de publicación: Polonia