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Orbitofrontal Circuits Control Multiple Reinforcement-Learning Processes.
Groman, Stephanie M; Keistler, Colby; Keip, Alex J; Hammarlund, Emma; DiLeone, Ralph J; Pittenger, Christopher; Lee, Daeyeol; Taylor, Jane R.
Afiliación
  • Groman SM; Department of Psychiatry, Yale University, New Haven, CT 06515, USA. Electronic address: stephanie.groman@yale.edu.
  • Keistler C; Department of Psychiatry, Yale University, New Haven, CT 06515, USA.
  • Keip AJ; Department of Psychiatry, Yale University, New Haven, CT 06515, USA.
  • Hammarlund E; Department of Psychiatry, Yale University, New Haven, CT 06515, USA.
  • DiLeone RJ; Department of Psychiatry, Yale University, New Haven, CT 06515, USA; Department of Neuroscience, Yale University, New Haven, CT 06515, USA.
  • Pittenger C; Department of Psychiatry, Yale University, New Haven, CT 06515, USA; Child Study Center, Yale University, New Haven, CT 06515, USA.
  • Lee D; Department of Psychiatry, Yale University, New Haven, CT 06515, USA; Department of Neuroscience, Yale University, New Haven, CT 06515, USA; Department of Psychology, Yale University, New Haven, CT 06515, USA.
  • Taylor JR; Department of Psychiatry, Yale University, New Haven, CT 06515, USA; Department of Neuroscience, Yale University, New Haven, CT 06515, USA; Department of Psychology, Yale University, New Haven, CT 06515, USA. Electronic address: jane.taylor@yale.edu.
Neuron ; 103(4): 734-746.e3, 2019 08 21.
Article en En | MEDLINE | ID: mdl-31253468
Adaptive decision making in dynamic environments requires multiple reinforcement-learning steps that may be implemented by dissociable neural circuits. Here, we used a novel directionally specific viral ablation approach to investigate the function of several anatomically defined orbitofrontal cortex (OFC) circuits during adaptive, flexible decision making in rats trained on a probabilistic reversal learning task. Ablation of OFC neurons projecting to the nucleus accumbens selectively disrupted performance following a reversal, by disrupting the use of negative outcomes to guide subsequent choices. Ablation of amygdala neurons projecting to the OFC also impaired reversal performance, but due to disruptions in the use of positive outcomes to guide subsequent choices. Ablation of OFC neurons projecting to the amygdala, by contrast, enhanced reversal performance by destabilizing action values. Our data are inconsistent with a unitary function of the OFC in decision making. Rather, distinct OFC-amygdala-striatal circuits mediate distinct components of the action-value updating and maintenance necessary for decision making.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Refuerzo en Psicología / Aprendizaje Inverso / Corteza Prefrontal Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Neuron Asunto de la revista: NEUROLOGIA Año: 2019 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Refuerzo en Psicología / Aprendizaje Inverso / Corteza Prefrontal Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Neuron Asunto de la revista: NEUROLOGIA Año: 2019 Tipo del documento: Article Pais de publicación: Estados Unidos