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Stabilization of microtubules by cevipabulin.
Nasrin, Syeda Rubaiya; Rashedul Kabir, Arif Md; Konagaya, Akihiko; Ishihara, Tsukasa; Sada, Kazuki; Kakugo, Akira.
Afiliación
  • Nasrin SR; Graduate School of Chemical Sciences and Engineering, Hokkaido University, Sapporo, 060-0810, Hokkaido, Japan.
  • Rashedul Kabir AM; Faculty of Science, Hokkaido University, Sapporo, 060-0810, Hokkaido, Japan.
  • Konagaya A; Department of Computational Intelligence and Systems Science, Tokyo Institute of Technology, Yokohama, 226-8502, Japan.
  • Ishihara T; Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Ibaraki, 305-8566, Japan.
  • Sada K; Graduate School of Chemical Sciences and Engineering, Hokkaido University, Sapporo, 060-0810, Hokkaido, Japan; Faculty of Science, Hokkaido University, Sapporo, 060-0810, Hokkaido, Japan.
  • Kakugo A; Graduate School of Chemical Sciences and Engineering, Hokkaido University, Sapporo, 060-0810, Hokkaido, Japan; Faculty of Science, Hokkaido University, Sapporo, 060-0810, Hokkaido, Japan. Electronic address: kakugo@sci.hokudai.ac.jp.
Biochem Biophys Res Commun ; 516(3): 760-764, 2019 08 27.
Article en En | MEDLINE | ID: mdl-31253401
We report the utility of cevipabulin as a stabilizing agent for microtubules. Cevipabulin-stabilized microtubules were more flexible compared to the microtubules stabilized by paclitaxel, the most commonly used microtubule stabilizing agent. Similar to the paclitaxel-stabilized microtubules, cevipabulin-stabilized microtubules were driven by kinesins in an in vitro gliding assay. The velocity of cevipabulin-stabilized microtubules was significantly higher than that of paclitaxel-stabilized microtubules. These findings will enrich the variety of microtubules with difference in mechanical and dynamic properties and widen their applications in nanotechnology.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Triazoles / Tubulina (Proteína) / Simulación del Acoplamiento Molecular / Hidrocarburos Halogenados / Microtúbulos Límite: Animals Idioma: En Revista: Biochem Biophys Res Commun Año: 2019 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Triazoles / Tubulina (Proteína) / Simulación del Acoplamiento Molecular / Hidrocarburos Halogenados / Microtúbulos Límite: Animals Idioma: En Revista: Biochem Biophys Res Commun Año: 2019 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Estados Unidos