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Association of Symptoms of Obstructive Lung Disease and All-Cause Mortality in Older Adult Smokers.
Opina, Maria Theresa D; Nicklas, Barbara J; Lovato, James F; Files, Daniel C; Kritchevsky, Stephen B; Moore, Wendy C.
Afiliación
  • Opina MTD; Section on Pulmonary, Critical Care, Allergy, and Immunologic Disease, Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina.
  • Nicklas BJ; Sticht Center on Healthy Aging and Alzheimer's Prevention, Wake Forest School of Medicine, Winston-Salem, North Carolina.
  • Lovato JF; Sticht Center on Healthy Aging and Alzheimer's Prevention, Wake Forest School of Medicine, Winston-Salem, North Carolina.
  • Files DC; Section on Gerontology and Geriatric Medicine, Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina.
  • Kritchevsky SB; Division of Public Health Sciences, Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina.
  • Moore WC; Section on Pulmonary, Critical Care, Allergy, and Immunologic Disease, Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina.
J Am Geriatr Soc ; 67(10): 2116-2122, 2019 10.
Article en En | MEDLINE | ID: mdl-31250432
OBJECTIVES: This study aims to investigate the impact of respiratory symptoms in current and former smokers with and without obstructive lung disease (OLD) on all-cause mortality. DESIGN: Secondary analysis in a prospective cohort (the Health, Aging and Body Composition study). SETTING: Memphis, Tennessee, and Pittsburgh, Pennsylvania. PARTICIPANTS: Black and white men and women with a history of current and former smoking (N = 596; 63% male and 37% female) aged 70-79 years followed for 13 years. Participants were categorized into 4 mutually exclusive groups based on symptom profile and forced expiratory volume in the 1st second to forced vital capacity ratio. The groups were Less Dyspnea-No OLD (N = 196), More Dyspnea-No OLD (N = 104), Less Dyspnea-With OLD (N = 162), and More Dyspnea-With OLD (N = 134). MEASUREMENTS: All-cause mortality. RESULTS: Overall, 53% in Less Dyspnea-No OLD, 63% in More Dyspnea-No OLD, 67% in Less Dyspnea-With OLD, and 84% in More Dyspnea-With OLD died within the 13- year follow up period (log-rank χ2 = 44.4, P < .0001). The hazard ratio was highest for participants with OLD, both with (HR =1.91, 95% CI 1.44 - 2.54; P < .0001) and without dyspnea (HR = 1.52, 95% CI 1.15 - 2.02; p = .004). Participants without OLD but with dyspnea had a similar risk of death to subjects who had OLD but fewer symptoms. CONCLUSIONS: OLD is associated with high risk of death with different risk profiles based on symptom group. Patients with symptoms of shortness of breath without OLD should be considered an at-risk group given their similar mortality to those with OLD with minimal symptoms. J Am Geriatr Soc 67:2116-2122, 2019.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fumar / Tos / Enfermedad Pulmonar Obstructiva Crónica / Disnea Tipo de estudio: Diagnostic_studies / Etiology_studies / Observational_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male Idioma: En Revista: J Am Geriatr Soc Año: 2019 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fumar / Tos / Enfermedad Pulmonar Obstructiva Crónica / Disnea Tipo de estudio: Diagnostic_studies / Etiology_studies / Observational_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male Idioma: En Revista: J Am Geriatr Soc Año: 2019 Tipo del documento: Article Pais de publicación: Estados Unidos