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sRAGE plays a role as a protective factor in the development of PCOS by inhibiting inflammation.
Wang, Bi-Jun; Qian, Li; Li, Jing; Wang, Fang; Yang, Qing-Ling; Li, Gang; Liang, Yu-Ling; Guo, Yi-Hong.
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  • Wang BJ; Reproductive Medical Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
  • Qian L; Reproductive Medical Center, the Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
  • Li J; Reproductive Medical Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
  • Wang F; Reproductive Medical Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
  • Yang QL; Reproductive Medical Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
  • Li G; Reproductive Medical Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
  • Liang YL; Reproductive Medical Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
  • Guo YH; Reproductive Medical Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Gynecol Endocrinol ; 36(2): 148-151, 2020 Feb.
Article en En | MEDLINE | ID: mdl-31248316
This study determined the effect of exogenous soluble receptor for advanced glycation end products (sRAGE) on the pro-inflammatory activities that occur during polycystic ovary syndrome (PCOS) in human follicular cells and explored a potential mechanism for preventing the development of inflammation. Follicular fluid was allocated into one of three treatment groups (0, 0.6, and 1.2 µg mL-1 of sRAGE). Collectively, these results indicate that exogenous sRAGE supplementation alleviates inflammation in ovarian follicular granulosa cells by regulating p-ERK and AP-1 signaling.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Síndrome del Ovario Poliquístico / Receptor para Productos Finales de Glicación Avanzada / Células de la Granulosa / Inflamación Límite: Adult / Female / Humans Idioma: En Revista: Gynecol Endocrinol Asunto de la revista: ENDOCRINOLOGIA / GINECOLOGIA Año: 2020 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Síndrome del Ovario Poliquístico / Receptor para Productos Finales de Glicación Avanzada / Células de la Granulosa / Inflamación Límite: Adult / Female / Humans Idioma: En Revista: Gynecol Endocrinol Asunto de la revista: ENDOCRINOLOGIA / GINECOLOGIA Año: 2020 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido